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胃切除手术后急性肾损伤预测模型的验证
Validation of acute kidney injury model after gastric resection surgery
投稿时间:2023-12-05  修订日期:2024-04-09
DOI:
中文关键词:  术后急性肾损伤  胃切除手术  机器学习  预测模型  特征选择。
英文关键词:Postoperative acute kidney injury  Gastric resection surgery  Machine learning  Predictive model  Feature selection.
基金项目:2021年省卫生健康面上项目(2021KY443)
作者单位邮编
章锃宇 浙江中医药大学第二临床医学院 310053
唐思宇 浙江中医药大学第二临床医学院 
瞿燕 浙江中医药大学第二临床医学院 
徐柏 浙江省人民医院 杭州医学院附属人民医院 重症医学科 
杨向红 浙江省人民医院(杭州医学院附属人民医院)重症医学科 
金善恩* 浙江省人民医院 310014
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中文摘要:
      摘要:目的:本研究旨在通过机器学习方法,包括决策树、逻辑回归和随机森林,预测胃切除手术后术后急性肾损伤(acute kidney injury ,AKI)的风险,并深入分析关键预测因子。方法:选取浙江省人民医院2021年1月至2022年12月间接受全身麻醉下胃切除手术的患者。收集人口统计学数据和术中、术前、术后实验室检查等信息。采用决策树、逻辑回归和随机森林三种机器学习模型,通过特征选择和模型性能评估,确定最佳预测模型。进一步采用逐步前向logistic 回归法,分析胃切除手术后术后急性肾损伤风险预测因子。结论:随机森林模型在AUC值(AUC=0.91,95% CI: (0.8074, 0.9686))上表现最佳,表明其对不同数据和复杂关系具有良好适应性。男性性别、糖尿病、术前中性粒细胞分类、术中碳酸氢根、晶体液入量、术后的超敏C反应蛋白等是胃切除手术后术后急性肾损伤关键的风险预测因子。研究为个体化管理提供了新的可能性,也为相关研究和临床实践提供了指导。
英文摘要:
      Abstract:Objective: This study aims to predict the risk of postoperative acute kidney injury (AKI) after gastric resection surgery using machine learning methods, including decision trees, logistic regression, and random forests. Additionally, it seeks to conduct an in-depth analysis of key predictive factors. Methods: Patients who underwent general anesthesia for gastric resection surgery at Zhejiang Provincial People's Hospital between January 2021 and December 2022 were selected. Demographic data, intraoperative, preoperative, and postoperative laboratory examination information were collected. Three machine learning models—decision tree, logistic regression, and random forest—were employed. Through feature selection and model performance evaluation, the optimal predictive model was determined. Conclusion: The random forest model exhibited the best performance in terms of AUC (AUC=0.91, 95% CI: (0.8074, 0.9686)), demonstrating its adaptability to different data and complex relationships. Important predictive factors included male gender, diabetes, preoperative neutrophil classification, intraoperative bicarbonate, crystalloid fluid intake, and postoperative high-sensitivity C-reactive protein. The study provides new possibilities for personalized management and offers guidance for related research and clinical practice.
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