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针刺蝶腭神经节联合布地奈德鼻喷剂治疗常年性变应性鼻炎的疗效研究
Observation on the therapeutic effect of acupuncture of sphenopalatine ganglionon perennial allergic rhinitis:a retrospective cohort Study
投稿时间:2021-08-26  修订日期:2021-11-11
DOI:
中文关键词:  鼻炎  常年性  变应性  针刺  蝶腭神经节
英文关键词:rhinitis  perennial  allergic  acupuncture  sphenopalatine ganglion
基金项目:杭州市生物医药和健康产业发展扶持科技专项研发
作者单位邮编
代丽丽 杭州师范大学附属医院 310011
汤维 杭州师范大学 
李凯杰 杭州师范大学 
尤悦 杭州师范大学 
周雪华 杭州师范大学附属医院耳鼻喉科 
倪嘉俞 杭州师范大学 
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中文摘要:
      目的:观察蝶腭神经节针刺治疗常年性变应性鼻炎近期与远期疗效。方法:采用回顾性队列研究方法,选取2017年2月至2018年2月杭州师范大学附属医院耳鼻咽喉科门诊就诊的变应性鼻炎120例患者,分为暴露组(60例,针刺蝶腭神经节+常规布地奈德鼻喷雾剂(雷诺考特)治疗和非暴露组(60例,常规布地奈德鼻喷雾剂(雷诺考特)治疗。分别在治疗前、治疗8周后及2年后采用鼻部症状总评分(TNNS) 对患者临床疗效、鼻部分类症状进行评价,并通过鼻阻力检测对患者鼻腔通气功能评定,记录治疗过程中发生的不良反应。结果:两组治疗前TNNS评分和鼻阻力组间比较差异无统计学意义(P>0.05)。治疗2年后暴露组TNNS评分明显低于非暴露组,差异具有统计学意义(t=12.806,P<0.05)。暴露组治疗8周后及2年后暴露组鼻阻力均低于非暴露组,差异具有统计学意义(t=6.330、98.109,P<0.05)。治疗8周后和2年后暴露组总有效率均明显高于非暴露组,组间比较结果显示Waldχ2组别=4.518,P<0.05,组间差异有统计学意义;重复测量时间比较结果显示,Waldχ2时点=11.819,P<0.05。暴露组不良反应发生率为15%,非暴露组为0,组间比较有统计学意义(χ2=9.73,P<0.05)。结论:针刺蝶腭神经节联合雷诺考特治疗常年性变应性鼻炎近远期疗效显著,能在较短时间内缓解症状,降低鼻阻力。
英文摘要:
      Objective To observe the short-term and long-term efficacy of sphenopalatine ganglion acupuncture in the treatment of perennial allergic rhinitis. Methods A retrospective cohort study using clinical data on 120 patients with allergic rhinitis in the Department of Otolaryngology, Affiliated Hospital of Hangzhou Normal University from February 2017 to February 2018. All subjects were divided into exposure group and non-exposure group, 60 cases in each group. The non-exposure group was treated with Budesonide Nasal Spray (Reynold court), and the exposure group was treated with acupuncture of sphenopalatine ganglion on the basis of the non-exposure group. The total nasal symptom score (TNNS) was used to evaluate the clinical efficacy and nasal symptoms before treatment, 8 weeks after treatment and 2 years after treatment,besides nasal ventilation function was evaluated by nasal resistance test. The adverse reactions during the treatment were recorded. Results There was no significant difference in TNNS score and nasal resistance between the two groups before treatment (P > 0.05). After 2 years of treatment, the TNNS score of the exposure group was significantly lower than that of the non-exposure group (t = 12.806, P < 0.05). After 8 weeks and 2 years of treatment, the nasal resistance of the exposure group was lower than that of the non-exposure group, and the difference was statistically significant (t = 6.330, P < 0.05). After 8 weeks and 2 years of treatment, the total effective rate of the exposure group was significantly higher than that of the non-exposure group, and the results showed that Waldχ2group=4.518,P<0.05. The comparison of repeated measurement time showed that Waldχ2point of time=11.819,P<0.05. The incidence of adverse reactions was 15.0% in the exposure group and 0 in the non-exposure group, containing a statistical difference (χ2= 9.73, P < 0.05). Conclusion Acupuncture of sphenopalatine ganglion has a good short-term and long-term effect in the treatment of perennial allergic rhinitis, which can effectively relieve symptoms and reduce nasal resistance.
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