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MIA蛋白对非小细胞肺癌患者肿瘤临床分期、组织分化程度的影响
The effect of MIA protein on the clinical staging and tissue differentiation of patients with non-small cell lung cancer
投稿时间:2021-07-14  修订日期:2021-11-12
DOI:
中文关键词:  黑色素瘤抑制性活性蛋白  非小细胞肺癌中  肿瘤临床分期  组织分化  相关性
英文关键词:melanoma inhibitory active protein  non-small cell lung cancer  tumor clinical staging  tissue differentiation  correlation
基金项目:浙江省自然科学LY16H160001
作者单位邮编
谢忠海 湖州市中心医院胸心外科 313000
沈琦斌 湖州市中心医院胸心外科 
李冬 湖州市中心医院胸心外科 
顾勤花 湖州市中心医院胸心外科 
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中文摘要:
      目的研究黑色素瘤抑制性活性(Melanoma Inhibitory Active, MIA)蛋白在非小细胞肺癌中的表达,对比其对患者肿瘤临床分期、组织分化程度的影响。方法选择2019年5月至2021年5月本院住院治疗的非小细胞肺癌患者86例纳入本次研究,采用免疫组化标记envision法测定非小细胞肺癌患者肿瘤组织MIA蛋白表达,探究其对患者肿瘤临床分期、组织分化程度的相关性。结果非小细胞肺癌、癌旁细胞组织均有MIA阳性表达,其中非小细胞肺癌细胞阳性染色部分显示为弥漫性分布,包膜胞浆内呈现棕黄和棕褐色团块,细胞核内无分布,癌旁细胞组织阳性染色部分显示浅黄色。非小细胞肺癌细胞组织内MIA表达和肿瘤临床分期、淋巴结转移、组织分化程度存在密切相关性(P<0.05);Ⅲ-Ⅳ期非小细胞肺癌、癌旁组织细胞MIA表达均明显高于Ⅰ-Ⅱ期,且非小细胞肺癌MIA表达高于癌旁组织(P<0.05);高分化非小细胞肺癌、癌旁组织细胞中MIA表达高于中分化、低分化,且非小细胞肺癌MIA表达高于癌旁组织(P<0.05)。结论MIA蛋白能够有效抑制非小细胞肺癌细胞的转移和分化,阻断患者肿瘤内血管形成,有利促进非小细胞肺癌细胞的凋亡。
英文摘要:
      Objective To study the expression of Melanoma Inhibitory Active (MIA) protein in non-small cell lung cancer, and to compare its effects on the clinical staging and tissue differentiation of patients.Methods86cases of patients with non-small cell lung cancer who were hospitalized in our hospital from May 2019 to May 2021 were selected for this study.The immunohistochemical marker envision method was used to determine the expression of MIA protein in tumor tissues of patients with non-small cell lung cancer, and to explore its correlation with the clinical staging and tissue differentiation of patients.Results MIA was positively expressed in non-small cell lung cancer and adjacent cell tissues. Among them, the positive staining part of non-small cell lung cancer cells showed diffuse distribution, with brownish-yellow and tan clumps in the envelope cytoplasm, and no distribution in the nucleus. The positive staining part of the adjacent cell tissues showed light yellow.The expression of MIA in non-small cell lung cancer cell tissues is closely related to the clinical stage of the tumor, lymph node metastasis, and the degree of tissue differentiation (P<0.05);
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