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楼学航,郭兰中.环磷酰胺与雷公藤治疗老年人原发性肾病综合征疗效比较楼学航郭兰中1[J].浙江中西医结合杂志,2014,24(9):
环磷酰胺与雷公藤治疗老年人原发性肾病综合征疗效比较楼学航郭兰中1
Cyclophosphamide and Tripterygium wilfordii treatment in elderly patients with nephrotic syndrome curative effect comparisonLou xue-hang,Guo lan-zhong(Women and Children"s Hospital,Dongyang,Zhejiang)
投稿时间:2014-01-17  修订日期:2014-03-09
DOI:
中文关键词:  环磷酰胺  雷公藤多甙  老年人原发肾病综合征
英文关键词:cyclophosphamide  Tripterygium wilfordii  elderly primary nephrotic syndrom.
基金项目:
作者单位E-mail
楼学航 浙江省东阳市妇幼保健医院 larlflxh@sina.cn 
郭兰中   
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中文摘要:
      【目的】观察环磷酰胺(cyclophosphamide,CTX)与雷公藤多甙(tripterygium wilfordii,TW)治疗老年人原发性肾病综合征的疗效。【方法】回顾性分析41例老年人原发性肾病综合征患者,CTX组22例(静脉滴注CTX 0.6-0.8g/次,半月1次*2次,1月1次*4次,以后每3月1次,累积总量约0.8-1.0g);TW组19例(口服TW 20mg 3/日,缓解后减量维持)。两组同时服用半量激素(强的松龙片)30mg, 8周后逐渐减量,每月减2.5-5mg,以后5-10 mg/d维持治疗。定期检测24小时尿蛋白定量、血清白蛋白、血常规、肝肾功能等指标,对患者治疗期间的缓解率进行观察。【结果】患者两组24小时尿蛋白定量及血浆白蛋白水平较治疗前明显好转(P<0.05),治疗前后血常规及肝肾功能未见明显变化,缓解率无统计学差异(P>0.05)。【结论】环磷酰胺及雷公藤能有效诱导老年人原发性肾病综合征缓解。
英文摘要:
      [Objective]To evaluate the efficacy and rucurrent rate of cyclophosphamide(CTX) and tripterygium wilfordii(TW)inthe treatment on the elderly primary nephrotic syndrome.[Methods] a retrospective analysis of 41 cases of elderly patients with primary nephrotic syndrome,22 cases in group CTX (intravenous infusion of CTX 0.6-0.8g/, a 1 *2 times, in January 1 times *4 times, after each in March 1, the cumulative total of approximately 0.8-1.0g);19 cases in TW group (oral TW 20mg 3/ day, maintain remission after reduction). The two group also took half the amount of hormone (prednisolone tablet) 30mg, 8 weeks after the gradual reduction, monthly by 2.5-5mg, after 5-10 mg/d maintenance therapy.Quantitative measurement of 24 hours urinary protein, serum albumin, blood routine, liver and kidney function were regularly, on patients during remission rate were observed.[Results] in patients of two groups of 24 hours urine protein and plasma albumin levels than before treatment significantly improved (P<0.05), there was no obvious changes in blood and liver function before and after treatment, remission rate showed no significant difference (P>0.05).[Conclusion] cyclophosphamide and Tripterygium wilfordii could effectively induce elderly primary nephrotic syndrome remission.
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