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周仁希,吴亦栋,陈刚.EV71型手足口病患儿血清心肌酶谱的变化及临床价值[J].浙江中西医结合杂志,2014,24(7):
EV71型手足口病患儿血清心肌酶谱的变化及临床价值
Analysis of serum myocardial enzymes in children with hand, foot and mouth disease induced by enterovirus 71 and its clinical significance ZHOU Renxi,WU Yidong,CHENGang.( Hangzhou Childrens Hospital, Hangzhou 310014)
投稿时间:2014-01-13  修订日期:2014-04-15
DOI:
中文关键词:  EV71  手足口病  心肌酶谱
英文关键词:Enterovirus 71 Hand, foot and mouth disease Myocardial enzyme spectrum
基金项目:浙江省自然科学基金资助项目(NO.LY13H040007);杭州市科技发展计划项目(NO.20130733Q40)
作者单位E-mail
周仁希 杭州市儿童医院检验科 zrxtcm@163.com 
吴亦栋 杭州市儿童医院检验科  
陈刚   
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中文摘要:
      目的 探讨EV71型手足口病患儿血清心肌酶谱的变化及其临床价值。方法 收集杭州市儿童医院收治的111例EV71型手足口病患儿(HFMD组)为研究对象,其中重症病例87例,并选取67名健康体检儿童作为对照组,采用全自动生化分析仪检测两组血清心肌酶谱水平,并对其结果进行统计学分析。结果 EV71型HFMD组心肌酶谱各项指标及异常率均显著高于健康对照组,两组比较差异均有统计学意义(P<0.01或P<0.05),EV71型HFMD重症病例组CK-MB的异常率明显高于普通病例组,两组比较差异有统计学意义(P<0.05)。结论 在EV71型手足口病尤其是重症患儿的诊治中,应对患儿进行心肌酶谱检查,有助于了解心肌的损伤情况,以便及时采取积极有效的治疗措施。
英文摘要:
      Objective To investigate the role of serum myocardialSenzyme in children with hand, foot and mouth disease(HFMD) induced by enterovirus 71(EV71) and its clinical significance. Methods A total of 111 patients in Hangzhou Children¢s Hospital with HFMD induced by EV71 were enrolled, including 87 severe HFMD patients. Meanwhile 67 matched healthy children were collected as control. The levels of serum myocardialSenzyme in children with HFMD and healthy children were measured by automatic biochemistry analyzer. Results The levels of serum myocardialSenzyme in HFMD group were significantly higher than those in control group(P<0.01 or P<0.05). The abnormalSrateSof CK-MB in severe HFMD patients was obviouslyShigherSthanSthat in ordinary patients(P<0.05). Conclusion The levels of serum myocardialSenzyme were closely related to myocardial damage in patients with HFMD, especially with severe HFMD. Detecting the levels of serum myocardialSenzyme is helpful to find the degree of myocardial injury in patients with HFMD in order to discover the illness complication promptly and take treatment effectively.
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