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曲丕盛,黄丽霞,范皓,李娜.经皮吗啡自控镇痛治疗晚期癌痛的临床观察[J].浙江中西医结合杂志,2014,24(6):
经皮吗啡自控镇痛治疗晚期癌痛的临床观察
Clinical Observation of Patient-Controlled Analgesia Percutaneous Morphine Pumping in Patients with Cancer Pain
投稿时间:2014-01-08  修订日期:2014-01-21
DOI:
中文关键词:  自控镇痛  吗啡  晚期癌痛
英文关键词:Patien-controlled analgesia, Morphine, Cancer pain
基金项目:
作者单位E-mail
曲丕盛 杭州市红十字会医院 doctorqu@163.com 
黄丽霞   
范皓   
李娜   
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中文摘要:
      目的:评价应用自控镇痛微控皮下吗啡给药对晚期癌痛的疗效及安全性。方法:对2012年7月—2013年7月住院期间的38例晚期癌痛口服阿片类药物效果不佳患者,应用吗啡自控镇痛泵以代替其口服吗啡用药,记录治疗前后3天疼痛评分(VAS)、生活质量评分-2(QOL-2)及24小时吗啡总用量,观察疼痛缓解率及不良反应并记录。结果:应用镇痛泵前后VAS评分均值分别为7.16±0.89和1.79±0.38(P<0.01),QOL-2评分均值分别为28.34±6.57 和50.03±8.41(P<0.01),治疗前后吗啡日用量分别为92.6±21.01mg(口服剂量)和31.0±9.34mg(皮下给药)(P<0.01);疼痛缓解率为94.7%(36/38);不良反应发生主要为便秘、恶心呕吐、尿潴留和精神症状。结论:经皮下吗啡给药自控镇痛可有效控制晚期癌痛,具有安全、高效、方便的优点,并降低晚期癌痛患者的吗啡药物的用量及药物不良反应。
英文摘要:
      Objective To investigate the efficacy and safety of patient-controlled analgesia percutaneous morphine pumping in patients with cancer pain. Methods A total of 38 patients with cancer pain underwent continuous percutaneous morphine via patient-controlled analgesia pump from July, 2012 to July, 2013. And to evaluate the time of beginning pain relief, pain intensity, the degree of pain relief and its adverse reaction. And to compare the visual analogue scale(VAS) and QOL and morphine consumption before and after treatment. Results The VAS befor and after treatment were 7.16 ±0.89and 1.79±0.38 respectively(P<0.01), QOL were 28.34±6.57 and 50.03±8.41(P<0.01), morphine consumptions were 92.6±21.01mg and 31.0±9.34mg. The degree of pain relif was 94.7%(36/38). The The main adverse reaction was nausea, vomiting, constipation and urine retention. Conclusion patien-controlled analgesia continuous percutaneous morphine pumping is effective, safe in treatment of cancer pain.
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