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陈志阳,吴福斌,潘敏.中药治疗联合生活干预对糖尿病前期患者血糖及早期相胰岛素分泌水平的影响[J].浙江中西医结合杂志,2015,25(1):
中药治疗联合生活干预对糖尿病前期患者血糖及早期相胰岛素分泌水平的影响
投稿时间:2013-12-19  修订日期:2014-10-29
DOI:
中文关键词:  糖尿病前期  早期相胰岛素分泌 中药治疗  生活干预
英文关键词:Prediabetes  early-phase insulin secretion  Chinese-Herbs therapy  Lifestyle intervention
基金项目:糖尿病前期中医证型与尿液成分变化的相关性研究,温岭市科技局计划项目,2013WLCB0099.
作者单位E-mail
陈志阳 浙江台州 温岭市第一人民医院 中西医结合病区 317500 czy6419@163.com 
吴福斌   
潘敏   
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中文摘要:
      目的 本研究旨在观察中药治疗联合生活干预对糖尿病前期患者血糖及早期相胰岛素分泌水平的影响。方法:本研究采用随机对照研究方法,一共纳入140例患者,所有患者均符合2012年美国ADA关于糖尿病前期的诊断标准,将研究对象随机分成治疗组及对照组共2组,治疗组给予中药治疗及生活干预,对照组只给予生活干预,疗程总共8周,分别在研究前及研究结束后测空腹血糖、糖化血红蛋白、血清胰岛素浓度,并计算胰岛素浓度曲线下面积(AUCins)、早期相胰岛素分泌指数(ΔI30/ΔG30)。结果:对比两组在空腹血糖、餐后2H血糖、糖化血红蛋白水平,治疗组得到明显的改善,差异具有显著统计学意义(P<0.01)。治疗组早期相胰岛素分泌峰值出现明显早于对照组,且胰岛素曲线下面积大于对照组(P<0.01),治疗组胰岛素分泌指数与对照组比较有显著提高(P<0.01)。结论:中药治疗联合生活干预对比生活干预可使糖尿病前期患者血糖更大的改善,并可明显改善早期相胰岛素分泌水平,使胰岛素功能改善,且安全性良好。
英文摘要:
      objective The objective of this study was to observed the impact of Chinese-Herbs therapy combined with lifestyle intervention on blood glucose and early-phase insulin secretion in prediabetes patient . Methods: In this study, a randomized controlled study included a total of 140 patients , all patients was established by the 2012 American ADA about pre-diabetes diagnostic criteria , the patients were randomly divided into treatment group and control group were two groups, the treatment group received Chinese-Herbs therapy combined with lifestyle intervention and control group given only the intervention of lifestyle , a total of eight weeks of treatment , respectively, on the beginning and end of the study, fasting blood glucose 、glycated hemoglobin、serum insulin concentrations were obtained;the area of insulin concentrations to be calculated under the curve (AUCins), with early-phase insulin secretion Index(ΔI30/ΔG30). Results: The comparison of the two groups in fasting blood glucose, postprandial 2H glucose, glycated hemoglobin serum levels , significantly improved in the treatment group , the difference was statistically significant (P <0.01). early-phase insulin secretion of the treatment group had peaked significantly earlier than the control group , and the area of insulin under the curve was bigger than the control group (P <0.01), insulin secretion index had significantly increased compared with the control group (P <0.01). Conclusion : Chinese-Herbs therapy combined with life intervention can improve blood glucose levels more efficient in patients with pre-diabetes who only was given the life intervention,and significantly improve the early-phase insulin secretion , theβcell function of islet,but less side effect
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