| 吉康宇,姚力芳,梁艳.视网膜中央静脉阻塞继发黄斑水肿抗VEGF治疗后出现棉绒斑增多2例[J].浙江中西医结合杂志,2023,33(12): |
| 视网膜中央静脉阻塞继发黄斑水肿抗VEGF治疗后出现棉绒斑增多2例 |
| Two Cases of Increased Cotton-wool Spots after Anti-VEGF Treatment for Macular Edema Secondary to Central Retinal Vein Occlusion |
| 投稿时间：2023-05-23 修订日期：2023-11-06 |
| DOI： |
| 中文关键词: 视网膜静脉阻塞 黄斑水肿 抗VEGF治疗 棉绒斑 缺氧 炎症因子 |
| 英文关键词:Retinal vein occlusion macular edema anti-VEGF treatment cotton-wool spots hypoxia inflammatory factors |
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| 中文摘要: |
| 视网膜静脉阻塞(retinal vein occlusion,RVO)是全球第二大高发的视网膜血管性疾病,按照其发病部位分为视网膜中央静脉阻塞（central retinal vein occlusion，CRVO）
和视网膜分支静脉阻塞（branch retinal vein occlusion，BRVO），其发病机制复杂。目前抗血管内皮生长因子(anti-vascular endothelial growth factor,anti-VEGF)治疗是一线治疗，临床上发现2例患者在接受抗VEGF治疗后出现视网膜棉绒斑短暂性增多情况，本文推测棉绒斑的出现可能与眼内VEGF水平被过度抑制和炎症因子的高度表达造成视网膜急性缺血缺氧相关，但具体的分子机制还需要进一步研究证实。 |
| 英文摘要: |
| Retinal vein occlusion (RVO) is the second most common retinal vascular disease in the world, which can be divided into central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) according to its location. The mechanism of RVO is complex. Currently, anti-vascular endothelial growth factor (anti-VEGF) therapy is the first-line treatment. However, two cases of increased retinal cotton wool spots were observed after anti-VEGF treatment, which may be related to acute retinal ischemia and hypoxia caused by excessive inhibition of intraocular VEGF levels and high expression of inflammatory factors. The specific molecular mechanism still needs further research. |
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