| 潘涛,池学锋,褚滋泓.MEIS1基因多态性与血液透析维持不宁腿综合征的相关性研究[J].浙江中西医结合杂志,2023,33(12): |
| MEIS1基因多态性与血液透析维持不宁腿综合征的相关性研究 |
| Relationship between MEIS1 gene polymorphism and restless leg syndrome maintained by hemodialysis |
| 投稿时间：2023-03-03 修订日期：2023-06-08 |
| DOI： |
| 中文关键词: 血液透析维持 不宁腿综合征 髓系亲嗜性白血病病毒整合位点 1 基因多态性 |
| 英文关键词:Hemodialysis maintenance restless leg syndrome integration site of myeloid hereditary leukemia virus 1 gene polymorphism |
| 基金项目:温州市科研项目 |
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| 中文摘要: |
| 目的：探究髓系亲嗜性白血病病毒整合位点 1（myeloid ecotropic viral integration site 1，MEIS1）基因多态性与血液透析维持不宁腿综合征（RLS）的相关性。方法：选取2021年5月-2022年5月在我院进行血液透析维持患者，入选符合纳入标准的病例，选血液透析维持伴RLS组患者40例，特发性RLS组患者30例，另选年龄和性别相匹配的健康体检者40例作对照组。给予基因多态性检测、实验室指标及MRI监测。结果：采用Logistic回归分析，显示MEIS1基因多态性的2个位点表达变化与血液透析维持伴RLS患者与特发性RLS患者疾病的发生有关（P<0.05）；MEIS1基因rs113851554、rs1820989多态性与尿素清除指数（Kt/V）、血钙（Ca）水平无关，无统计学差异（P>0.05）；与尿素氮（BUN）、β2-微球蛋白（β2-MG）、血肌酐（Scr）、血清无机磷（P）、转铁蛋白饱和度（TS）、血红蛋白（Hb）、C-反应蛋白（CRP）、甲状旁腺激素（PTH）表达相关（P<0.05）；MEIS1基因rs113851554、rs1820989多态性与MRI参数的幅度log值及RMSI值有关联（P<0.05）；发现MEIS1基因s1820989、rs113851554多态性均与MRI参数RMSI值、幅度log值有关（P<0.05）。结论：Logistic回归分析发现，MEIS1基因中rs113851554、rs1820989基因多态性与发生血液透析维持伴RLS有着紧密联系，呈现出种族特异性，为临床展开较大规模较多病例的研究对照对MEIS1基因进行明确，且与血液透析维持伴RLS具有一定的相关性。 |
| 英文摘要: |
| Objective: To explore the association of gene polymorphism of myeloid hereditary leukemia virus integration site 1 (myeloid ecotropic viral integration site 1, MEIS 1) and maintenance restless leg syndrome (RLS) on hemodialysis. Methods: Patients undergoing hemodialysis maintenance in our hospital from May 2021 to May 2022 were selected as cases who met the inclusion criteria, 40 patients in hemodialysis maintenance group with RLS, 30 patients with idiopathic RLS, and 40 patients with matched age and gender were selected as the control group. Genetic polymorphism testing, laboratory indicators, and MRI monitoring were administered. Results: Logistic regression analysis showed that the expression changes of two sites of MEIS1 gene polymorphism were related to the occurrence of diseases in patients with RLS and idiopathic RLS during hemodialysis maintenance (P<0.05). There was no significant difference between rs113851554 and rs1820989 polymorphism of MEIS1 gene and urea clearance index (Kt/V) and blood calcium (Ca) level (P>0.05). It was correlated with the expression of urea nitrogen (BUN), β2-microglobulin (β2-MG), serum creatinine (Scr), serum inorganic phosphorus (P), transferrin saturation (TS), hemoglobin (Hb), C-reactive protein (CRP) and parathyroid hormone (PTH) (P<0.05). (P<0.05). The polymorphisms of rs113851554 and rs1820989 of MEIS1 gene were associated with the amplitude log value and RMSI value of MRI parameters (P<0.05). It was found that the polymorphisms of MEIS1 gene s1820989 and rs113851554 were related to MRI parameter RMSI value and amplitude log value (P<0.05). Conclusion: Logistic regression analysis found that rs113851554 and rs1820989 gene polymorphisms in MEIS 1 were closely associated with the occurrence of hemodialysis maintenance with RLS, showing ethnic specificity, which defined the MEIS 1 gene for large clinical studies and more medical records, and had some correlation with hemodialysis maintenance with RLS. |
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