| 黄琪,王文婷,蒋凤春,何武剑,裴德安,王士生,隋向前.尼可地尔对原发性微血管心绞痛患者的疗效观察 [J].浙江中西医结合杂志,2023,33(12): |
| 尼可地尔对原发性微血管心绞痛患者的疗效观察 |
| Effect of nicorandil on patients with primary microvascular angina pectorisHUANG Qi, WANG Wen-ting, JIANG Feng-chun , HE Wu-jian, PEI De-an, WANG Shi-sheng, SUI Xiang-qian. Department of Cardiology, HangZhou Red Cross Hospital, HangZhou 310003, China. |
| 投稿时间：2023-01-23 修订日期：2023-10-11 |
| DOI： |
| 中文关键词: 原发性微血管心绞痛，尼克地尔，血管性假血友病因子，同型半胱氨酸，纤维蛋白肽A，血小板膜糖蛋白140 |
| 英文关键词:primary microvascular angina nicorandil von Willebrand factor homocysteine fibrinopeptide A platelet alpha-granule membrane glycoprotein 140 |
| 基金项目:浙江省医药卫生科技计划项目（2019KY510） |
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| 中文摘要: |
| 目的 分析原发性微血管心绞痛(primarymicrovascular angina, PMVA)患者使用尼可地尔治疗后血浆血管性假血友病因子(von Willebrand factor, vWF)、同型半胱氨酸(homocysteine, Hcy)、纤维蛋白肽A (fibrinopeptide A, FPA)以及血小板膜糖蛋白140(platelet alpha-granule membrane glycoprotein 140, GMP-140)水平的改变。方法 选择明确诊断为PMVA的患者45例,随机分为常规治疗组和尼克地尔组,同时选择正常体检人群43例作为正常对照组,测定所有入选对象的血vWF、Hcy、FPA以及GMP-140水平；尼可地尔组在常规治疗的基础上增加尼可地尔5mg tid口服治疗。结果 PMVA组患者[vWF(85.019±19.877mIU/ml)及FPA(735.424±168.323ng/ml)]水平较正常对照组[vWF(23.952±4.121mIU/ml)及FPA(263.731±118.287ng/ ml)]水平显著升高,P<0.01；PMVA组GMP-140(3.829±2.712ng/ml)水平较正常对照组GMP-140(9.209±5.529ng/ml)水平显著降低,P<0.01；PMVA组患者Hcy(11.898±4.695μmol/L)水平与正常对照组Hcy(12.879±1.926μmol/L)水平比较无显著性差异,P>0.05。入院时尼可地尔组患者[vWF (85.586±20.110mIU/ml)、Hcy (11.319± 4.482μmol/L)、FPA (707.266±157.700ng/ml)及GMP-140 (3.853±2.006 ng/ml)]水平分别与常规治疗组[vWF (84.477±20.087mIU/ml)、Hcy (12.453±4.925μmol/L)、FPA (762.357±177.130ng/ml)及GMP-140 (3.806±3.296ng/ml)]水平比较均无显著性差异,P>0.05。治疗后尼可地尔组患者的vWF (65.400±13.540mIU/ml)水平较入院时显著下降,P<0.01；FPA (876.367±125.807ng/ml)水平较入院时显著升高,P<0.01； |
| 英文摘要: |
| Objective To analyze the effect of nicorandil on plasma von Willebrand factor (vWF), homocysteine (Hcy), fibrinopeptide A (FPA) and platelet alpha granule membrane glycoprotein 140 (GMP-140) levels in patients with primary microvascular angina (PMVA). Methods 45 patients with PMVA diagnosed by clinical symptoms, electrocardiogram and coronary angiography were randomly divided into conventional treatment group and nicorandil group, and 43 healthy people were selected as normal control group; Patients in the conventional treatment group were given aspirin, atorvastatin, metoprolol and perindopril, while patients in the nicorandil group were given nicorandil 5mg TID oral treatment on the basis of conventional treatment. Results PMVA Group [vWF (85.019±19.877 mIU/ml) and FPA (735.424±168.323 ng/ml)] was significantly higher than that of the normal control group [vWF (23.952±4.121 mIU/ml) and FPA (263.731±118.287ng/ml)], P<0.01; PMVA group[GMP-140 (3.829±2.712 ng/ml)] was higher than that of the normal control group [GMP-140 (9.209±5.529ng/ml)], P<0.01; There was no significant difference in the level of PMVA group[Hcy(11.898±4.695μmol/L)] and normal control group[Hcy(12.879±1.926μmol/L)], P>0.05). There was no significant difference in admission level of nicorandil group [vWF (85.586±20.110mIU/ml)、Hcy (11.319±4.482μmol/)、FPA (707.266±157.700ng/ml) and GMP-140 (3.853±2.006ng/ml)] and conventional treatment group [vWF (84.477±20.087mIU/ml)、Hcy (12.453±4.925μmol/L)、FPA (762.357±177.130ng/ml) and GMP-140 (3.806±3.296ng/ml)], P>0.05. After treatment, the level of vWF (65.400±13.540mIU/ml) in nicodil group was significantly lower than that at admission (P<0.01); the level of FPA (876.367±125.807ng/ml) was significantly higher than that at admission (P<0.01); the level of GMP-140 (2.117±2.255ng/ml) was decreased significantly, P<0.05. the levels of vWF (75.794±27.198mIU/ml)、FPA (786.927±134.837ng/ml) and GMP-140 (3.234±2.881ng/ml) were not significantly changed compared with that at admission (P>0.05). Conclusions The levels of vWF and FPA in the PMVA group were significantly higher than those in the normal control group, and the level of GMP-140 in the PMVA group was significantly lower than that in the normal control group, but there was no significant difference in the level of Hcy between the two groups; The vascular endothelial function and platelet activity in the nicorandil group were significantly improved after nicorandil additional treatment compared with those in the conventional treatment group. |
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