| 谢敏,郑娟红,陈烁.血清尿酸/肌酐比值与成人非酒精性脂肪肝的相关性[J].浙江中西医结合杂志,2022,32(5): |
| 血清尿酸/肌酐比值与成人非酒精性脂肪肝的相关性 |
| Association of the Serum Uric Acid-to-Creatinine Ratio with Nonalcoholic Fatty Liver Disease in Adults |
| 投稿时间：2021-07-04 修订日期：2021-07-20 |
| DOI： |
| 中文关键词: 血清尿酸/肌酐比值 非酒精性脂肪肝 尿酸 肌酐 |
| 英文关键词:Serum uric acid-to-creatinine ratio Non-alcoholic fatty liver disease Uric acid Creatinine |
| 基金项目: |
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| 中文摘要: |
| 目的：明确血清尿酸/肌酐比值 (SUA/Cr)与成人非酒精性脂肪肝（NAFLD）的相关性。
方法：收集本院的487例健康体检者临床资料进行横断面调查研究。采用腹部B超判定所有研究对象肝脏脂肪变性，将研究对象分为非NAFLD组（对照组）(n=259)和NAFLD组(n=228)；比较2组基线临床资料、各血清生化指标的差异；采用ROC曲线分析SUA/Cr预测NAFLD的临床价值；采用Logistic回归模型分析NAFLD的危险因素，评估SUA/Cr的比值比(OR)和95%置信区间。
结果：NAFLD组SUA/Cr平均水平显著高于对照组，差异具有统计学意义（P＜0.05）。ROC曲线分析显示SUA/Cr预测患者NAFLD发病风险的最佳临界值为4.66，曲线下面积为0.719（P＜0.05），敏感度和特异度分别为70.6%和65.3%。多因素Logistic回归分析表明SUA/Cr≥4.66与NAFLD发病率存在正相关，调整后OR值为4.907（95%CI：3.187-7.557，P＜0.001)。
结论：SUA/Cr升高与成人NAFLD发病风险独立相关，SUA/Cr可能是预测 NAFLD 的可靠标志物。 |
| 英文摘要: |
| Objective To investigated the association between the serum uric acid-to-creatinine ratio (SUA/Cr) and NAFLD in adults.
Methods A cross-sectional analysis was performed in 487 subjects who participated in a health examination at the hospital where the author works. The fatty infiltration of the liver was determined by abdominal ultrasound. The participants were grouped as non-NAFLD (control group) (n=259) and NAFLD groups (n=228). Clinical and biochemical parameters in NAFLD patients compared with non-NAFLD patients. The ROC curve analysis was used to explore the value of SUA/Cr in predicting the outcome of NAFLD. Multiple logistic regression analysis was performed to explore the association between SUA/Cr and NAFLD, and an adjusted odds ratio (OR) of SUA/Cr for NAFLD was estimated.
Results In NAFLD group, the mean SUA/Cr was significantly higher than that of control group. There was a positive correlation between SUA/Cr and NAFLD. In ROC curve analysis ，the optimum cut-off value for SUA/Cr in diagnosis of NAFLD subjects was 4.66 and the area under the ROC curve for SUA/Cr was 0.719（P＜0.05），with a sensitivity of 70.6% ,a specificity of 65.3%.In multivariate analysis, SUA/Cr levels were positively associated with NAFLD presence, and the adjusted OR of SUA/Cr≥4.66 for NAFLD was 4.907（95%CI：3.187-7.557，P＜0.001)
Conclusions Elevated SUA/Cr was independently associated with NAFLD in adults. SUA/Cr may be a reliable marker for predicting NAFLD. |
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