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戴赢杰,魏 建,石仕元.阳和汤联合抗结核西药治疗阳虚寒凝型脊柱结核的短期临床效果[J].浙江中西医结合杂志,2022,32(5):
阳和汤联合抗结核西药治疗阳虚寒凝型脊柱结核的短期临床效果
The short-term clinical effect of Yanghe decoction combined with antituberculosis western medicine in the treatment of spine tuberculosis of yang deficiency and cold coagulationDai Ying Jie1,Wei Jian1,Shi Shi Yuan2
投稿时间:2021-04-19  修订日期:2021-11-30
DOI:
中文关键词:  阳和汤  脊柱结核  阳虚寒凝型结核  短期临床效果
英文关键词:Yanghe Decoction  spinal tuberculosis  yang deficiency and cold coagulation tuberculosis  short-term clinical effects
基金项目:浙江省中医药科技计划科研基金项目(2020ZA084)
作者单位E-mail
戴赢杰 浙江中医药大学第二临床医学院 xjzvvip@163.com 
魏 建 浙江大学医学院附属杭州市胸科医院  
石仕元* 浙江大学医学院附属杭州市胸科医院 ssylf@sina.com 
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中文摘要:
      目的:探讨阳和汤联合抗结核西药治疗阳虚寒凝型脊柱结核的短期临床疗效。方法:回顾性分析2019年3月至2020年3月于我科住院治疗明确诊断为阳虚寒凝型脊柱结核患者60例,将所收集的病例依照随机数字表法分为治疗组(阳和汤联合抗结核西药组)30例和对照组(单纯抗结核西药组)30例。观察对比两组患者治疗前后中医证候疗效及疼痛视觉模拟量表评分(visual analogue scale,VAS) 变化情况,采用ELISA法对CRP、血沉及TNF-α的水平进行测定。结果:治疗3周内,两组患者畏寒发热、面色苍白、腰膝冷痛、腹胀等中医证候积分均下降(P<0.05)。两组间比较,治疗组中医证候积分降低更显著(P<0.05);治疗组总有效率96.70%,对照组总有效率73.30%,治疗组患者的中医证候疗效要好于对照组,差异有统计学意义(X2=4.71,P<0.05);治疗组患者血沉、CRP、TNF-α指标比对照组有更显著的降低,差异有统计学意义(P<0.05)。结论:阳和汤联合抗结核西药对阳虚寒凝型脊柱结核短期治疗效果显著,能明显改善患者临床症状,降低患者血炎症因子水平,具有广泛的应用前景和推广意义。
英文摘要:
      Objective: To explore the short-term clinical effect of Yanghe Decoction combined with anti-tuberculosis western medicine in treating spinal tuberculosis of yang deficiency and cold coagulation. Methods: A retrospective analysis of 60 patients with spine tuberculosis who were hospitalized in our department from March 2019 to March 2020 were clearly diagnosed with yang deficiency and cold coagulation type. The collected cases were divided into treatment groups (yang and Decoction combined with anti-tuberculosis western medicine group) 30 cases and control group (only anti-tuberculosis western medicine group) 30 cases. To observe and compare the curative effect of TCM syndromes and pain visual analogue scale (VAS) changes between the two groups of patients before and after treatment. The levels of CRP, erythrocyte sedimentation rate and TNF-α were measured by ELISA. Results: Within 3 weeks of treatment, the scores of TCM syndromes such as chills and fever, pale complexion, cold waist and knee pain, and abdominal distension in the two groups decreased (P<0.05). Compared between the two groups, the TCM syndrome scores of the treatment group decreased more significantly (P<0.05); the total effective rate of the treatment group was 96.70%, and the total effective rate of the control group was 73.30%. The TCM syndromes of the treatment group were better than the control group. There was a difference. It was statistically significant (X2=4.71, P<0.05); the erythrocyte sedimentation rate, CRP, and TNF-α indexes of the treatment group were significantly lower than those of the control group, and the difference was statistically significant (P<0.05). Conclusion: Yanghe Decoction combined with anti-tuberculosis western medicine has a significant short-term therapeutic effect on spine tuberculosis of yang deficiency and cold coagulation type. It can significantly improve the clinical symptoms of patients and reduce the level of blood inflammatory factors. It has broad application prospects and promotion significance.
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