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陈静,任少平,吴志全.肝癌液体活检的研究进展(综述)[J].浙江中西医结合杂志,2021,31(6):
肝癌液体活检的研究进展(综述)
Research progress of Liquid biopsy of liver cancerChen Jin1 Ren Shaoping2 Wu Zhiquan3
投稿时间:2021-01-02  修订日期:2021-03-03
DOI:
中文关键词:  临床意义  展望  液体活检  肝癌
英文关键词:Clinical significance  Outlook  liquid biopsy  Primary liver cancer
基金项目:
作者单位E-mail
陈静 浙江省医疗健康集团杭州医院外科 218814@sina.com 
任少平 浙江义乌市復元医院 rsp1616@sina.com 
吴志全 上海中山医院肝癌研究所  
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中文摘要:
      原发性肝癌(PLC)是一种发病率高,死亡率高,手术切除率低,术后易复发转移的恶性肿瘤。液体活检是将人体体液或者血液中的某些微小的成分通过特殊的方法富集,再进行浓缩,扩增和荧光染色等处理后,用专门的设备进行检测,从而了解体液中具有的肿瘤或基因特征的信息,实现了对人体内的肿瘤相关状态从新的角度进行监测的方法。液体活检研究提供了可能早期发现肝癌,评估术后疗效和预后的新途径。液体活检技术主要包括循环肿瘤细胞(CTCs)、循环游离核酸(CFNA)和外泌体(exosomes)检测,它们在检测技术和临床应用方面各有特色,新近的PCR+分子测序技术将有助于此项研究。作者对肝癌液体活检的几种类型和特点进行综述并展望了未来的发展方向。
英文摘要:
      Primary liver cancer (PHC) is a malignant tumor with high morbidity, high mortality, low surgical resection rate, and easy recurrence and metastasis after surgery. Liquid biopsy is to enrich some tiny components in human body fluids or blood through special methods, then concentrate, amplify, and fluorescent dyes, and then use special equipment to detect them, so as to understand the tumors or tumors in the body fluids. The information of gene characteristics realizes the method of monitoring the tumor-related state in the human body from a new perspective. Liquid biopsy research provides a new way to detect liver cancer early and evaluate postoperative efficacy and prognosis. Liquid biopsy technology mainly includes circulating tumor cells (CTCs), circulating free nucleic acid (CFNA) and exosomes detection. They have their own characteristics in detection technology and clinical application. The recent PCR+ molecular sequencing technology will help this Studies. The author summarized its type and feature , looked forward to the future development direction.
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