| 陈琼琰,俞宁宁,葛金林,杨欢欢,曾余丰,金晨慈.哮喘患者皮质醇水平与焦虑抑郁及病情控制的相关性分析[J].浙江中西医结合杂志,2021,31(5): |
| 哮喘患者皮质醇水平与焦虑抑郁及病情控制的相关性分析 |
| Correlation analysis of cortisol level with clinical indicators such as anxiety and depression in asthmatic patients |
| 投稿时间：2020-10-25 修订日期：2021-01-12 |
| DOI： |
| 中文关键词: 皮质醇 哮喘 焦虑 抑郁 |
| 英文关键词:Cortisol Asthma Anxiety Depression |
| 基金项目:温州市基础性科研项目 |
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| 中文摘要: |
| 目的：探讨不同血浆皮质醇水平的哮喘患者一般情况、焦虑抑郁评分、哮喘控制测试（asthma control test, ACT）评分、肺功能之间的异同及其相关性。方法： 根据早晨8时皮质醇水平将哮喘患者分为低皮质醇组和正常皮质醇组，比较两组患者一般情况、皮质醇水平、焦虑抑郁评分、ACT评分、肺功能等指标，同时分析哮喘患者皮质醇水平与一般情况、焦虑抑郁评分、ACT评分、肺功能之间的相关性。结果：（1）低皮质醇组哮喘患者病程长，焦虑抑郁评分高于正常皮质醇组，ACT评分、肺功能均低于正常皮质醇组，差异均具有统计学意义(均P0.05)。（2）哮喘患者皮质醇与病程、使用糖皮质激素、焦虑抑郁评分呈负相关(r=-0.403~-0.639, P0.05)，与ACT评分、肺功能呈正相关(r=0.370~0.442, P0.05)。结论：哮喘患者皮质醇水平与焦虑抑郁情况、病程、控制情况、肺功能具有相关性，低皮质醇组哮喘患者病程更长，焦虑抑郁更明显，肺功能及控制情况更差，检测皮质醇水平对哮喘患者有重要意义。 |
| 英文摘要: |
| Objective To explore the difference and correlation among the general situation, anxiety and depression score, asthma control test(ACT) score and lung function of asthma patients with different plasma cortisol level. Methods Asthma patients were divided into low cortisol and normal cortisol groups according to cortisol level at 8 morning. We compared the general situation, cortisol level, anxiety and depression score, ACT score, lung function and other indicators between the two groups. At the same time, the correlation between cortisol level and general condition, anxiety and depression score, ACT score and lung function was analyzed. Results (1) The course of asthma in low cortisol group was longer, anxiety and depression score was higher than that in normal cortisol group, ACT score and lung function were lower than that in normal cortisol group, the difference was statistically significant(all P0.05). (2) The level of cortisol in asthmatic patients was negatively correlated with course of disease, glucocorticoid use, anxiety and depression score (r=-0.403~-0.639, P0.05), and positively correlated with ACT score and pulmonary function (r=0.370~0.442, P0.05). Conclusion The level of cortisol in asthmatic patients is correlated with anxiety and depression, course of disease, asthma control and lung function. In low cortisol group, the course of disease is longer, anxiety and depression are more obvious, lung function and control are worse. Detection of cortisol level is of great significance to asthmatic patients. |
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