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杜晓平,邱根祥,许宝才,方昉.胃癌患者血前白蛋白/纤维蛋白原比值与临床病理特征及预后的相关研究[J].浙江中西医结合杂志,2021,31(4):
胃癌患者血前白蛋白/纤维蛋白原比值与临床病理特征及预后的相关研究
Detection of pre-albumin/fibrinogen ratio in patients with gastric cancer and its clinical significance
投稿时间:2020-10-18  修订日期:2021-01-13
DOI:
中文关键词:  胃癌  前白蛋白  纤维蛋白原  病理特征  预后
英文关键词:Gastric cancer  Prealbumin  Fibrinogen  Pathological features  Prognosis
基金项目:
作者单位E-mail
杜晓平 衢州市中医医院 1667285925@qq.com 
邱根祥 衢州市中医医院  
许宝才 衢州市中医医院  
方昉 衢州市中医医院  
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中文摘要:
      目的 探讨不同临床病理特征胃癌患者的前白蛋白/纤维蛋白原(PA/Fib)比值,探讨其与预后的关系。方法 选择2017年1月~2019年4月收治的86例胃癌患者作为研究对象,收集患者临床资料,比较不同临床病理特征患者的PA/Fib值,采用Pearson相关性分析PA/Fib值与NLR、PLR的关系,比较不同PA/Fib值的患者预后情况。结果 胃癌患者平均Pa/Fib值为(9.07±3.20),胃癌患者PA/Fib值与脉管浸润、神经侵犯无明显相关性(P>0.05),与肿瘤大小、TNM分期、浸润深度、淋巴结转移、肿瘤分化程度显著相关(P<0.05);胃癌患者PA/Fib值与NLR、PLR呈负相关(P<0.05);高PA/Fib组患者术后1年生存率明显高于低PA/Fib组(P=0.047)。结论 胃癌患者PA/Fib值与临床病理特征和NLR、PLR等预后指数具有相关性,可用于胃癌患者疾病进展和预后判断的辅助观察。
英文摘要:
      Objective To investigate the pre-albumin/fibrinogen (PA/Fib) ratio in gastric cancer patients with different clinicopathologic features, and to evaluate the degree of tumor progression. Methods Clinical data of 86 patients with gastric cancer admitted from January 2017 to April 2019 were analyzed, and PA/Fib of patients with different clinicopathological characteristics were compared. The relation between PA/Fib and NLR and PLR was analyzed by Pearson correlation, the prognosis of patients with different PA/Fib values was compared. Results The average Pa/Fib value of gastric cancer patients was (9.07±3.20). There was no significant correlation between the Pa/Fib value and vascular invasion and nerve invasion (P>0.05), and the Pa/Fib was significantly correlated with tumor size, TNM stage, invasion depth, lymph node metastasis and tumor differentiation (P<0.05). PA/Fib value of gastric cancer patients was negatively correlated with NLR and PLR (r=-0.396, -0.345, P<0.05). The 1-year postoperative survival rate of patients in the high PA/Fib group was significantly higher than that in the low PA/Fib group (χ2=3.957, P=0.047). Conclusion The PA/Fib value of gastric cancer patients is correlated with the clinicopathological features, NLR and PLR, which can be used as an auxiliary observation indicator for the disease progression and prognosis of gastric cancer patients.
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