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蔡超丽,林成雷,林婷婷,梅淑芬,邵征洋.自拟咳喘口服液对热性哮喘患儿的临床疗效及IL-12、TNF-α和IL-10、TGF-β的影响[J].浙江中西医结合杂志,2021,31(4):
自拟咳喘口服液对热性哮喘患儿的临床疗效及IL-12、TNF-α和IL-10、TGF-β的影响
clinical effect of Kechuan koufuye(咳喘口服液) on children with heat asthma and the regulation on the levels of cell factor IL-12、TNF-α and IL-10、TGF-β of peripheral blood cytokines
投稿时间:2020-09-16  修订日期:2020-12-18
DOI:
中文关键词:  热性哮喘  小儿  IL-10  TGF-β
英文关键词:heat asthma  children  IL-10  TGF-β
基金项目:浙江省中医药科技计划(2018ZA092)
作者单位E-mail
蔡超丽 浙江中医药大学第二临床医学院 1114655797@qq.com 
林成雷 浙江中医药大学第二临床医学院  
林婷婷 浙江中医药大学第二临床医学院  
梅淑芬 浙江省中西医结合医院儿科  
邵征洋 浙江省中西医结合医院儿科 szy218@sina.com 
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中文摘要:
      摘要: 目的 观察咳喘口服液对热性哮喘患儿的临床疗效和外周血中IL-12、TNF-α和IL-10、TGF-β的影响。方法 50例健康体检儿童为对照组,64例哮喘急性发作期患儿为实验组,比较两组血清IL-12、TNF-α及IL-10、TGF-β水平的差异。将实验组患儿按照随机数字表法分为基础组和中药组,各32例。基础组予常规西医治疗,中药组在基础组治疗方法的基础上加用咳喘口服液治疗,疗程均为1周。比较两组的临床疗效、血清IL-12、TNF-α及IL-10、TGF-β水平的差异。结果 中药组喘息、咳嗽、肺部啰音消失时间和住院时间均明显短于基础组,2 组差异有统计学意义( P<0.05) 。治疗前,实验组患儿外周血炎症因子IL-10和TGF-β水平较对照组明显升高。治疗后,中药组患儿IL-10、TGF-β表达水平均下降,且较基础组差异有统计学意义( P<0.05) 。结论 咳喘口服液不仅可以缩短临床症状、体征消失时间和住院时间,而且可以改善外周血炎症因子IL-10和TGF-β水平,缓解哮喘发作,提高儿童免疫功能,且安全性较好。
英文摘要:
      Abstract: Objective To investigate the clinical effect of Kechuan koufuye(咳喘口服液) on children with heat asthma and the regulation on the levels of cell factor IL-12、TNF-α and IL-10、TGF-β of peripheral blood cytokines.Method 50 cases healthy children as control group and 64 cases of acute attack of bronchial asthma in children as cexperimental group,and peripheral blood cytokines (IL-12、TNF-αand IL-10、TGF-β) were compared between the two group. 64 cases of heat asthma, according to random number table method is divided into basic and traditional Chinese medicine group, 32 cases each,The basic group received conventional western medicine treatment, and the traditional Chinese medicine group received Kechuan koufuye treatment on the basis of the basic group treatment.After 1 week of treatment, compared the basic group and the traditional Chinese medicine group of clinical efficacy, and peripheral blood cytokines (IL-12、TNF-αand IL-10、TGF-β).Results The disappearance time of wheezing, cough, pulmonary rales and hospital stay in the traditional Chinese medicine group were significantly shorter than those in the basic group, and the difference between the two groups was statistically significant (P<0.05).Before treatment, the levels of inflammatory cytokines IL-10 and TGF- in peripheral blood of experimental children were significantly higher than those of the control group.After treatment, the expression levels of IL-10 and TGF-βin the children in the traditional Chinese medicine group were decreased, and the differences were statistically significant compared with the basic group (P < 0.05).Conclusion Kechuan koufuye has a satisfactory efficacy in the treatment of children with heat asthma, which can not only shorten the time of disappearance of clinical symptoms and signs and the length of hospital stay, but also decreased the the levels of cell factor IL-10 and TGF-β of peripheral blood cytokines, relieve asthma, improve children's immune function, and is safe.
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