| 张熳媛,田菲,周冰之.NLR、PLR与晚期非小细胞肺癌预后的相关性分析[J].浙江中西医结合杂志,2021,31(5): |
| NLR、PLR与晚期非小细胞肺癌预后的相关性分析 |
| Correlation analyses of NLR and PLR with Prognosis for advanced NSCLC respectively |
| 投稿时间：2020-09-10 修订日期：2021-04-09 |
| DOI： |
| 中文关键词: 晚期非小细胞肺癌 中性粒细胞-淋巴细胞比值 血小板-淋巴细胞比值 |
| 英文关键词:Non-small cell lung cancer Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio |
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| 中文摘要: |
| 目的 探讨中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比率（PLR）与晚期非小细胞肺癌（NSCLC）患者临床病理特征的相关性及其对预后的影响。方法 采用回顾性研究，选择2017年1月—2018年7月就诊于天津中医药大学第一附属医院肿瘤科的晚期NSCLC患者62例为研究对象，其中男42例，女20例，年龄35～86（65.60±8.91）岁，分析晚期NSCLC患者临床病理特征中年龄、性别、吸烟史、病理类型、临床分期、辨证分型、NLR、PLR与预后的相关性，对晚期NSCLC患者预后的影响因素进行单因素及多因素分析。结果 晚期NSCLC患者不同TNM分期的NLR[ⅢB期（3.26±1.16），Ⅳ期（3.92±1.34）]、PLR[ⅢB期（166.59±44.78），Ⅳ期（206.85±68.55）]差异有统计学意义（P＜0.05），晚期NSCLC患者病理分型中鳞癌（4.17±1.29）与腺癌（3.42±1.19）NLR水平比较差异有统计学意义（P＜0.05），晚期NSCLC患者中医辨证中痰热阻肺型（222.13±75.45）与肺阴虚型（151.04±29.16）PLR水平比较差异有统计学意义（P＜0.05）；晚期NSCLC患者TNM分期、中医虚实辨证与高低NLR、PLR分组存在相关性（P＜0.05）；辨证证型不是晚期NSCLC患者无进展生存预后的影响因素（P＞0.05）；TNM分期、NLR、PLR是晚期NSCLC患者无进展生存预后的独立影响因素（P＜0.05）。结论 NLR、PLR对评估晚期NSCLC患者预后有一定预测价值。 |
| 英文摘要: |
| Objective The aims were to investigate the correlation of neutrophils/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) and clinical pathology of advanced non-small cell lung cancer (NSCLC); and the prognosis of predictive value of NLR and PLR. Methods A retrospective study was conducted on 62 patients with advanced NSCLC who visited Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from January 2017 to July 2018. Among the patients were 42 males and 20 females, aged 35 ~ 86 (65.60±8.91) years old. The correlation between age, gender, smoking history, pathological type, clinical stage, syndrome differentiation, NLR, PLR in the clinical pathology and prognosis of patients with advanced NSCLC was analyzed. Univariate and multivariate analyses were performed on the prognostic factors of patients with advanced NSCLC. Results There were significant differences in NLR[ⅢB Stage（3.26±1.16），IV Stage（3.92±1.34）] and PLR[IIIB Stage（166.59±44.78，IV Stage（206.85±68.55）] levels of patients with advanced NSCLC among different TNM stages (P < 0.05). In pathological types of patients with advanced NSCLC, significant difference was found between squamous carcinoma（4.17±1.29） and glandular cancer（3.42±1.19） (P < 0.05) in NLR; while in traditional Chinese medicine (TCM) syndrome differentiation of patients with advanced NSCLC, there were statistical difference in the Phlegm-heat resistance lung type（222.13±75.45） and lung Yin deficiency type（151.04±29.16） in PLR (P < 0.05). TNM stage and TCM syndrome differentiation of deficiency and excess of patients with advanced NSCLC were correlated with NLR and PLR levels, respectively (P < 0.05). Syndrome differentiation was not an influential factor of the progress free survival prognosis of patients with advanced NSCLC (P＞0.05). TNM stage, NLR and PLR were independent factors affecting the progress free survival prognosis of patients with advanced NSCLC (P < 0.05). Conclusion NLR and PLR possess predictive values for the prognosis of patients with advanced NSCLC. |
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