| 俞正秋,戴冠冕,冯思,蔡宛如.基于数据挖掘的蔡宛如教授治疗咳嗽变异性哮喘用药规律分析[J].浙江中西医结合杂志,2021,31(3): |
| 基于数据挖掘的蔡宛如教授治疗咳嗽变异性哮喘用药规律分析 |
| Analysis of Cai Wanru’s treatment of cough variant asthma based on data mining |
| 投稿时间：2020-08-23 修订日期：2021-01-04 |
| DOI： |
| 中文关键词: 咳嗽变异性哮喘 蔡宛如 数据挖掘 名医经验 |
| 英文关键词:cough variant asthma CAI Wanru data mining famous doctor’s experience |
| 基金项目:浙江省国医名师传承工作室及浙江省名老中医专家传承工作室建设项目 |
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| 中文摘要: |
| 摘要：目的：基于回顾性分析和数据挖掘的方法探寻蔡宛如教授辨治咳嗽变异性哮喘（cough variant asthma, CVA）的用药规律。方法：收集2019年7月1日至2020年7月1日蔡宛如教授治疗CVA的172首处方，运用频数分析、聚类分析和关联规则的方法进行数据挖掘。结果：共涉及中药97味，高频药物为桔梗、防风、柴胡、北沙参、麻黄、蝉衣；药物类别以清热药、补虚药、止咳平喘化痰药为主；药性以寒、温、平为主；药味以甘、苦、辛为主；归经以肺、胃、脾经为主；关联规则分析显示关联性强的主要有以疏风解表、止咳平喘，疏肝理气、燥湿化痰，养阴润肺、补肺健脾为功效的三类药物；高频药物聚类分析得到7组核心药物，体现了祛风止痉、宣肺平喘、化痰止咳、疏肝解郁、降气泄热、敛肺固表、滋阴清热、健脾益气的治法。结论：蔡宛如教授治疗CVA临床经验丰富，用药以寒凉、清补为主，尤其重视滋养肺津，补肺气、疏肝气、益脾气。 |
| 英文摘要: |
| Abstract: Objective: To explore the medication rule of Professor Cai Wanru in treating cough variant asthma (CVA) based on retrospective analysis and data mining. Methods: 172 prescriptions of Professor Cai in the treatment of CVA from July 1, 2019 to July 1, 2020 were collected, and the methods of frequency analysis, cluster analysis and association rules were used for data mining. Results: There were 97 kinds of traditional Chinese medicine were involved, and the high frequency medicines were Platycodon grandiflorum, Saposhnikovia divaricate Schischk, Radix Glehniae, ephedra, cicada clothing. The top three types of frequently applied CVA medicines by effect were heat-clearing medicines, energy-restoring medicines, antitussive-antiasthmatic-expectorant medicines. The top three properties were cold, warm and neutral. The top three tastes were sweetness, bitterness and acridity. The main meridians were lung, stomach and spleen. The association rule analysis showed that there was strong correlation among three types of medicines, and were applied by effect of dispelling wind to relieve exterior syndrome, suppressing cough and clamming panting, dispersing stagnated liver to regulate qi-flowing, removing dampness and phlegm, nourishing yin for moistening lung, invigorating lung and spleen. Seven central medicines were obtained by using clustering analysis, which showed the TCM therapies of dispelling wind for resolving convulsion, dispersing lung qi and clamming panting, resolving phlegm and suppressing cough, dispersing stagnated liver qi for relieving qi stagnation, downbearing qi and discharging heat, astringing lung and consolidation exterior, nourishing yin and clearing heat, invigorating spleen and benefiting qi. Conclusion: Professor Cai has rich clinical experience in the treatment of CVA, often uses cold and tonic medicines, especially pays attention to nourishing lung fluid, tonifying lung qi, soothing liver qi and benefiting spleen qi. |
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