| 李旭东,倪军,饶立科,翁宁,俞东容.非糖尿病腹透患者不同腹膜转运功能的临床特点及与预后的关系*[J].浙江中西医结合杂志,2021,31(3): |
| 非糖尿病腹透患者不同腹膜转运功能的临床特点及与预后的关系* |
| Clinical characteristics of different peritoneal transport functions in non-diabetic peritoneal dialysis patients and their relationship with prognosisLi Xudong? Ni Jun? Rao Like? Weng Ning? Yu Dongrong |
| 投稿时间：2020-08-13 修订日期：2021-01-06 |
| DOI： |
| 中文关键词: 腹膜透析 腹膜转运功能 临床特点 预后 |
| 英文关键词:peritoneal dialysis, peritoneal transport function, clinical characteristics, prognosis |
| 基金项目:阿托伐他汀对腹膜透析患者心血管事件及瘦素/脂联素的影响 |
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| 中文摘要: |
| 目的 了解不同腹膜转运功能的非糖尿病腹透（PD）患者的临床特点及其与预后的关系。方法 选取2016年9月-2016年10月本院腹透门诊随诊的终末期非糖尿病肾病PD患者，PET法评估腹膜转运功能及分组：高转运(hightransport,H)组；高平均转运组(high average transport,HA)；低平均转运组(low average transport,LA)和低转运组(low transport,L)，分析各组患者临床特点；随访至2020年7月31日，Kaplan－Meier方法进行各组生存分析。结果 共纳入176例患者，其中H组18例，HL组68例，LH组79例，L组11例。实验室指标显示HB、TG、LDL、P、PTH、nPCR、KT/V没有明显差异，白蛋白各组有显著差异（P<0.05）；LA组患者TC与HA组患者比较有明显下降（P<0.05），LA组Tccr与HA组比较有显著下降（P<0.05）。至随访末，10例患者改移植，26例患者改行血透，17例患者死亡，总死亡率9.65%，Kaplan－Meier分析各组腹透生存率及技术生存率没有明显差异。结论 腹透患者不同腹膜转运功能具有不同的临床特征，高转运PD患者较低转运患者有着更低的白蛋白，更容易致技术失败进入血透，但并不影响其远期预后。 |
| 英文摘要: |
| Purpose To explore the clinical characteristics of non-diabetic peritoneal dialysis (PD) patients with different peritoneal transport functions and their relationship with prognosis. Method Selected PD patients with end-stage non-diabetic nephropathy who were followed up in the peritoneal dialysis clinic of our hospital from September 2016 to October 2016. The PET method was used to evaluate the peritoneal transport function and grouping: high transport group(H); high average transport group (HA); low average transport group (LA) and low transport group (L), to analyze the clinical characteristics of each group of patients. The PD patients were followed up until July 31, 2020, and the Kaplan-Meier method was used for survival analysis of each group. Result A total of 176 patients were enrolled, including 18 in H group, 68 in HA group, 79 in LA group, and 11 in L group. Laboratory indicators showed that each group had no significant difference in HB, TG, LDL, P, PTH, nPCR, KT/V, and each group showed significant difference in albumin (P<0.05); Compared with patients in the HA group, the TC level of the LA group decreased significantly (P<0.05), and there was a significant decrease in Tccr (P<0.05). At the end of the follow-up, 10 patients were changed to transplantation, 26 patients were changed to hemodialysis, 17 patients died, and the total mortality rate was 9.65%. Kaplan-Meier analysis showed no significant difference in the survival rate of peritoneal dialysis and the technical survival rate of each group. Conclusion Different peritoneal transport functions of peritoneal dialysis patients have different clinical characteristics. PD patients with high transport have lower albumin than patients with low transport, and are more likely to cause technical failure to enter hemodialysis, but it does not affect their long-term prognosis. |
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