| 黄晓芳,张鹰,胡芳芳,柴鸣雷.气候因素对皮下特异性免疫治疗全身不良反应的影响[J].浙江中西医结合杂志,2021,31(3): |
| 气候因素对皮下特异性免疫治疗全身不良反应的影响 |
| Influence of climatic factors on systemic adverse reactions of subcutaneous immunotherapy |
| 投稿时间：2020-07-29 修订日期：2021-02-03 |
| DOI： |
| 中文关键词: 儿童 皮下特异性免疫治疗 环境湿度 环境温度 |
| 英文关键词:Children Subcutaneous immunotherapy Environmental humidity The environment temperature |
| 基金项目:杭州市卫生科技计划（一般项目） |
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| 中文摘要: |
| 目的 探讨气候因素、环境温湿度对皮下特异性免疫治疗(SCIT)全身不良反应的影响。方法 选取2016年6月~2020年5月的接受SCIT治疗的呼吸道变应性疾病患儿为研究对象,对治疗期间出现的不良反应及处理进行详尽的记录。搜集相应时间内杭州地区的气象资料,每日环境平均温湿度,通过统计学比较分析不同季节及不同的月平均环境温度和环境相对湿度全身不良反应的比例及组间差异。结果 SCIT全身不良反应发生率为 2.89%,9月、10月发生率最高(6.21%,7.04%),与其他月份比较,差异有统计学意义,P＜0.05；季节分布中以秋季发生率最高(4.66%),与其他季节比较,差异有统计学意义,P＜0.05。每次SCIT治疗前1个月的平均环境温度升至18℃以上不良反应比例增高,其中18~28℃温度区间发生率最高,组间差异有统计学意义,p＜0.05；SCIT治疗前1个月的平均环境湿度≥70%时全身不良反应发生率升高,但组间差异无统计学意义,P＞0.05。结论 秋季SCIT全身不良反应比例较高,可能与气候因素、环境温湿度有关。 |
| 英文摘要: |
| Objective To investigate the effects of climatic factors,environmental temperature and humidity on systemic adverse reactions of subcutaneous specific immunotherapy (SCIT). Methods Selected from June 2016 to May 2020 SCIT treatment of children with respiratory allergic diseases as the research object, and against the adverse reaction during the treatment and disposal of detailed records. Meteorological data were collected in Hangzhou area within the corresponding period, and the daily average environmental temperature and humidity were analyzed through statistical comparison to analyze the proportion of systemic adverse reactions and the differences between groups in different seasons and different monthly average environmental temperature and environmental relative humidity. Results The incidence of systemic adverse reactions of SCIT was 2.89%, the highest in September and October (6.21%,7.04%),and the difference was statistically significant compared with other months (P<0.05). In the seasonal distribution, the incidence was the highest in autumn (4.66%), and the difference was statistically significant compared with other seasons (P<0.05). 1 month before each SCIT treatment, the rate of adverse reactions increased when the average ambient temperature rose above 18℃, with the highest incidence in the temperature range between 18℃ and 28℃, with statistically significant difference between the groups (P<0.05). The incidence of systemic adverse reactions was increased when the average environmental humidity was ≥70% one month before SCIT treatment, but there was no statistically significant difference between the groups (P>0.05). Conclusion In autumn, SCIT has a higher proportion of systemic adverse reactions, which may be related to climatic factors, environmental temperature and humidity. |
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