| 马文骏,史婷婷,琚立萍,白明辉,陈小伟,吕虹,刘寿荣.97例杭州市新型冠状病毒肺炎临床特征及影响因素分析[J].浙江中西医结合杂志,2020,30(12): |
| 97例杭州市新型冠状病毒肺炎临床特征及影响因素分析 |
| Clinical characteristics and influence factors analysis of 97 cases COVID-19 in Hangzhou |
| 投稿时间：2020-04-14 修订日期：2020-11-26 |
| DOI： |
| 中文关键词: 新型冠状病毒肺炎 白蛋白 TG 相关性分析 |
| 英文关键词:: COVID-19 ALB TG Correlation analysis |
| 基金项目:新型冠状病毒肺炎临床诊疗体系的建立及其疗效评价的研究 |
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| 中文摘要: |
| 目的：通过分析我院收治的97例新型冠状病毒肺炎患者入院时的临床症状、实验室指标和影响疾病严重程度的相关因素,总结出新型冠状病毒肺炎的临床特征及与疾病严重程度相关的影响因素,以指导临床诊治。方法：收集我院收治的97例新型冠状病毒肺炎患者流行病学和临床资料,分析入院时肝肾功能、血脂、肌酶、电解质、B型脑利钠肽前体(BNP)、肌钙蛋白、凝血功能等实验室检查和胸部CT结果,并进行相关分析。结果：97例新型冠状病毒肺炎患者中,轻型12例(12.96%),普通型74例(76.85%),重型11例(10.19%)；有武汉旅游居住史或者接触过武汉人35例(36.08%)、发病前2周与确诊或疑似病例密切接触62例(63.91%)；发热71例(73.20%)、咳嗽57例(53.3%)、咳痰22(22.68%)、乏力22例(22.68%)；胸部CT未见明显异常15例(15.46%)、单侧肺炎20例(20.62%)、双侧肺炎62(63.92%)；年龄、白蛋白(Albumin, ALB)、TG、血清淀粉样蛋白A(Serum amyloid, SSA)、血钠和胸部CT表现在临床分型各组间比较具有统计学差异(P<0.05)；单因素相关性分析显示：年龄、TG、胸部CT与诊断分型成正相关；ALB与诊断分型成负相关。结论：本文收集病例以疫区输入型为主,临床分型以普通型为主；以发热、咳嗽、咳痰、乏力、TG升高、血钠降低、SSA升高、ALB降低、胸部CT呈现磨玻璃影改变为该病的主要临床特点；年龄、TG、胸部CT与诊断分型成正相关性；ALB与诊断分型负相关性。 |
| 英文摘要: |
| Objective: By analyzing the clinical symptoms, laboratory results and related factors affecting the disease severity of 97 patients with COVID-19 admitted to our hospital, the clinical characteristics of COVID-19 and the affecting factors related to the disease severity were summarized to guide the clinical diagnosis and treatment. Methods: Epidemiological and clinical data of 97 patients with COVID-19 admitted to our hospital were collected to perform relevant analysis of the laboratory results, including liver and kidney function tests, blood lipid, creatase, electrolytes, B-type brain natriuretic peptide precursor, troponin, coagulation function tests, etc., and the chest CT findings at the time of admission. Results: Among the 97 patients with COVID-19, 12 cases (12.96%) were mild cases, 74 cases (76.85%) were moderate cases, and 11 (10.19%) were severe cases; there were 35 cases (36.08%) who had a history of living or traveling in Wuhan and 62 cases (63.91%) who had close contact with confirmed or suspected cases in the 2 weeks before onset; there were 71 cases (73.20%) with fever, 57 cases (53.3%) with dry coughing, 22 cases (22.68%) of productive coughing and 22 cases (22.68%) with fatigue; chest CT showed no obvious abnormalities in 15 cases (15.46%), 20 cases (20.62%) of unilateral pneumonia and 62 cases (63.92%) of bilateral pneumonia; there were statistically significant differences in age, ALB, TG, SSA, serum sodium and chest CT findings among the groups of clinical subtypes(P<0.05); The single factor correlation analysis showed that: age, TG and chest CT findings were positively correlated with diagnostic subtypes; ALB was negatively correlated with diagnostic subtypes. Conclusion: The cases collected in this study were mainly imported from the epidemic area. The cases were mainly the moderate subtype; fever, dry cough, productive cough, fatigue, increased TG, decreased serum sodium, increased SSA, decreased ALB, and ground glass opacity in chest CT were the main clinical features of the disease; age, TG and chest CT findings were positively correlated with diagnostic subtypes; ALB was negatively correlated with diagnostic subtypes. |
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