| 王超超,蔡小巧,姜益,王文文,林胜芬,林永强.羟氯喹治疗IgA肾病的疗效研究[J].浙江中西医结合杂志,2020,30(12): |
| 羟氯喹治疗IgA肾病的疗效研究 |
| Effects of Hydroxychloroquine treatment for IgA Nephropathy |
| 投稿时间：2020-04-13 修订日期：2020-12-09 |
| DOI： |
| 中文关键词: IgA肾病 羟氯喹 24h尿蛋白定量；缓解 |
| 英文关键词:IgA nephropathy Hydroxychloroquine Proteinuria Remission |
| 基金项目:温州市科技计划项目 |
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| 中文摘要: |
| 目的 探讨羟氯喹（Hydroxychloroquine，HCQ）在IgA肾病（IgA Nephropathy，IgAN）中的应用价值。方法 32例24h尿蛋白为0.5-2.0g/24小时IgAN患者随机配对分配HCQ组和对照组，HCQ组维持原有双倍剂量肾素血管紧张素阻滞剂等常规治疗基础上口服HCQ 200mg，bid。观察尿蛋白缓解率、24h尿蛋白量、尿沉渣镜检红细胞计数、血肌酐、肾小球滤过率、血钾、血压等指标变化。结果 治疗24周时,HCQ组24h尿蛋白缓解9例（56.25%），对照组缓解3例（18.75%）;两组间缓解率有显著性差异(P<0.05）。与治疗前相比,两组24h尿蛋白定量有明显下降(P<0.05),但两组间无显著性差异(P>0.05)。治疗前后及两组间在尿红细胞计数、血肌酐、肾小球滤过率、血钾、血压指标上无显著性差异(P>0.05)。结论 HCQ对部分IgAN患者有改善蛋白尿的作用。 |
| 英文摘要: |
| 【Abstract】 Objective To evaluate the efficacy of Hydroxychloroquine（HCQ）in the treatment of IgA nephropathy(IgAN)．. Methods Thirty-two IgAN patients with persistent proteinuria (0.5–2.0g/24 h) despite treatment with RASI for 3 months were matched to receive HCQ and RASI (HCQ group) or continue RASI therapy (control group) for 24 weeks. Result Nine patients（56.25%) in HCQ group versus three patients (18.75%) in control group reach remission (P<0.05). By 24 weeks, The 24 hour proteinuria waswas 0.62±0.33mg(P = 0.000) and 0.74±0.42mg(P = 0.03) in HCQ group and controlgroup,which was significantly reduced compared with the baseline,respectively. Baseline proteinuria and histologic grades, blood pressure control and changes in urinary blood cell count、serum creatinine、eGFR、serum potassium and Blood pressure were not different between the two groups. Conclusion In selected patients with IgAN, HCQ is effective in ameliorating proteinuria. |
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