| 史向辉,严婷婷,沈洁,叶俏.淋巴B细胞表达情况与RA患者发病的关系[J].浙江中西医结合杂志,2020,30(11): |
| 淋巴B细胞表达情况与RA患者发病的关系 |
| The relationship between the expression of lymphoid B cells and the pathogenesis of RA |
| 投稿时间：2020-04-04 修订日期：2020-05-19 |
| DOI： |
| 中文关键词: CD19+CD24hiCD38hi Breg细胞 CD20+B细胞 CD5+B细胞 类风湿性疾病 相关性 |
| 英文关键词:CD19+CD24hiCD38hi breg cells CD20+ B cells CD5+ B cells Rheumatoid disease correlation |
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| 中文摘要: |
| 目的：研究CD19+CD24hiCD38hi Breg细胞、CD20+B细胞、CD5+B细胞表达情况与RA患者发病的关系。方法：选取2016年1月-2019年4月诊断的120例类风湿性关节炎患者作为研究对象，另选取同期健康体检患者120例做为对照组，比较两组患者的CD19+CD24hiCD38hi Breg细胞、CD20+B细胞、CD5+B细胞水平、不同严重程度患者的CD19+CD24hiCD38hi Breg细胞、CD20+B细胞、CD5+B细胞水平之间的差异，分析严重程度与CD19+CD24hiCD38hi Breg细胞、CD20+B细胞、CD5+B细胞水平的相关性。结果：观察组患者的CD19+CD24hiCD38hi Breg细胞、CD20+B细胞比例显著低于对照组，观察组患者的CD5+B细胞比例显著高于对照组，差异存在统计学意义（P＜0.05）；Ⅰ级类风湿性疾病患者的CD19+CD24hiCD38hi Breg细胞、CD20+B细胞比例显著高于Ⅱ级患者，Ⅰ级类风湿性疾病患者的CD5+B细胞比例显著低于Ⅱ级患者，患者的疾病严重程度与CD19+CD24hiCD38hi Breg细胞、CD20+B细胞的比例呈现负相关，与CD20+B细胞细比例呈现正相关。结论：CD19+CD24hiCD38hi Breg细胞、CD20+B细胞、CD5+B细胞表达情况与类风湿性疾病患者的相关性显著，可作为患者疾病进展的预测指标。 |
| 英文摘要: |
| Objective: To study the relationship between the expression of CD19+CD24hiCD38hi breg cells, CD20+ B cells and CD5+ B cells and the pathogenesis of RA. Methods: 120 patients with rheumatoid arthritis diagnosed from January 2016 to April 2019 were selected as the study object, and 120 healthy people in the same period were selected as the control group. CD19+CD24hiCD38hi breg cells, CD20+ B cells and CD5+ B cells, CD19+CD24hiCD38hi breg cells, CD20+ B cells and CD5+ B cells of patients with different severity were compared between the two groups.The correlation between the severity and the levels of CD19+CD24hiCD38hi breg cells, CD20+ B cells and CD5+ B cells was analyzed. Results: The proportion of CD19+CD24hiCD38hi breg cells and CD20+ B cells in the observation group was significantly lower than that in the control group, and the proportion of CD5+ B cells in the observation group was significantly higher than that in the control group, with a statistically significant difference. The proportion of breg cells and CD20 + B cells was significantly higher than that of grade II patients. The proportion of CD5 + B cells in grade I rheumatoid patients was significantly lower than that of grade II patients. The disease severity of patients was negatively correlated with the proportion of CD19+CD24hiCD38hi breg cells and CD20 + B cells, and positively correlated with the proportion of CD20 + B cells. Conclusion: The expression of CD19+CD24hiCD38hi breg cells, CD20+ B cells and CD5+ B cells were significantly correlated with the patients with rheumatoid disease, which could be used as a predictor of disease progression. |
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