| 胡洁茹,张霞燕,沈宵,张乾坤,梅紫薇,田伟强.3-5期CKD患者高磷血症发病情况及危险因素分析[J].浙江中西医结合杂志,2020,30(9): |
| 3-5期CKD患者高磷血症发病情况及危险因素分析 |
| Analysis of incidence and risk factors of hyperphosphatemia in patients with stage 3-5 CKD |
| 投稿时间：2020-03-16 修订日期：2020-09-08 |
| DOI： |
| 中文关键词: 慢性肾脏病 3-5期 高磷血症 危险因素 |
| 英文关键词:chronic kidney disease stage 3-5 hyperphosphatemia risk factors |
| 基金项目:浙江省药学会医院药学专项科研资助项目（2019ZYY49） |
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| 中文摘要: |
| SS目的：探讨3-5期CKD患者高磷血症发病情况并对其危险因素分析,以期为临床提供指导。方法：选取我院2017年1月~2019年1月我院收治的3-5期CKD患者820例,分析患者高血磷的发生情况,采用单因素分析方法分析血磷与年龄、性别、肾脏替代疗法(血液透析疗法、腹膜疗法)、肾功能、合并症(高血压病史、心血管病史、糖尿病病史)、蛋白尿、吸烟、饮酒、病因、透析龄,采用多因素logistic回归分析探讨影响血磷水平的因素。结果：820例3-5期CKD患者合并高磷血症者269例,发生率为32.80%,其中3期患者中高磷血症者为34例,占9.94%；4期患者中高磷血症者为77例,占30.67%；5期患者中高磷血症者为158例,占69.60%。单因素分析结果显示：两组在性别、年龄、合并糖尿病、合并高血压、蛋白尿、肾功能分期、透析龄差异具有统计学意义(P<0.05)。多因素logistic回归模型进一步分析,结果显示：性别为男性、透析龄长、肾功能分期为5期及合并高血压是高磷血症的独立危险因素。结论：男性、透析龄长、肾功能分期为5期及合并高血压是高磷血症的独立危险因素,对于合并危险因素的CKD患者更应该对其进行宣传教育,注意食用限磷食物及低蛋白食物,必要时可以给予磷结合剂。 |
| 英文摘要: |
| Objective: To investigate the incidence of hyperphosphatemia in patients with stage 3-5 CKD and to analyze the risk factors in order to provide guidance for the clinic. Methods: From January 2017 to January 2019 in our hospital a total of 820 patients with stage 3-5 CKD were enrolled to analyze the incidence of hyperphosphatemi. Single factor analysis was used to analyze blood phosphorus and age, sex and kidney alternative therapy (hemodialysis therapy, peritoneal therapy), renal function, comorbidities (history of hypertension, history of cardiovascular disease, history of diabetes), proteinuria, smoking, alcohol consumption, etiology and dialysis age, while multivariate logistic regression analysis was used to discuss factors of phosphorus levels. Results: Of the 820 patients with CKD 269 patients had hyperphosphatemia with the incidence of 32.80%. Among them, 34 patients with hyperphosphatemia were in the third phase accounted for 9.94%, 77 patients with hyperphosphatemia were in the fourth phase accounted for 30.67%, and 158 cases were in the fifth phase accounting for 69.60%. Univariate analysis showed that there were significant differences in terms of gender, age, diabetes mellitus, hypertension, proteinuria, renal function staging, and dialysis age between the two groups (P<0.05). Further analysis by multivariate logistic regression model showed that gender (male), long dialysis, renal function staging 5 and hypertension were independent risk factors for hyperphosphatemia. Conclusion: Male, long dialysis, renal function stage 5 and hypertension are independent risk factors for hyperphosphatemia. CKD patients with risk factors should be educated and given phosphorus-limited foods, low-protein foods and phosphorus binders if necessary. |
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