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沈誉芳,嵇宏亮,李雪峰.阿戈美拉汀治疗抑郁的疗效与安全性的Meta分析[J].浙江中西医结合杂志,2020,30(10):
阿戈美拉汀治疗抑郁的疗效与安全性的Meta分析
Efficacy and safety of agomelatine treating depression: A meta-analysis
投稿时间:2020-03-12  修订日期:2020-05-29
DOI:
中文关键词:  阿戈美拉汀  艾司西酞普兰  抑郁  Meta分析
英文关键词:agomelatine  escitalopram  depression  meta-analysis
基金项目:
作者单位E-mail
沈誉芳 湖州市第三人民医院 cife2004@126.com 
嵇宏亮 湖州市第三人民医院 hzsmart@163.com 
李雪峰 湖州市第三人民医院  
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中文摘要:
      摘要 目的 对阿戈美拉汀用于抗抑郁的效果及不良反应进行Meta分析。方法 系统检索CNKI、万方医学、Medbooks等数据库,检索时限为2000年01月01日至2020年01月31日,筛选阿戈美拉汀与艾司西酞普兰相比较治疗抑郁症的随机对照试验(RCT),比较阿戈美拉汀与艾司西酞普兰的疗效与安全性。借助Revman5.3软件对精选出来的文献研究进行Meta分析。结果 最终纳入9项研究。Meta分析结果显示:阿戈美拉汀组患者有效率[OR=0.97,95%CI=0.78~1.22,P=0.82]、治愈率[OR=1.06,95%CI=0.76~1.47,P=0.73]与对照组比较,差异无统计学意义;阿戈美拉汀组与对照组的抑郁量表终点评分与基线的差值比较[MD=-0.24,95%CI=-0.88~0.39,P=0.46],差异无统计学意义;阿戈美拉汀组与对照组不良反应发生比较[OR=0.56,95%CI=0.45~0.69,P<0.00001,I2=64%],差异有统计学意义。结论 阿戈美拉汀与艾司西酞普兰治疗抑郁症的疗效相当,且安全性还可以。
英文摘要:
      Abstract:Objective The antidepressant effect and adverse reactions of agomelatine through a meta-analysis. Methods A systematic literature search was conducted in the CNKI、Wanfang Data、Medbook databases from January 1st,2000 to January 31st,2020.Screening of agomelatine versus escitalopram for the treatment of depression in a randomized controlled trial (RCT),to compare the efficacy and safety of agomelatine and escitalopram.Meta analysis was conducted on selected literature studies with the help of Revman5.3 software. Results 9 RCTs were included herein. Results of Meta-analysis showed that there were no significant differences between agomelatine and escitalopram on response[OR=0.97,95%CI=0.78~1.22,P=0.82]、remission rate[OR=1.06,95%CI=0.76~1.47,P=0.73].Depression scale at the end of the scale and the baseline values was without significant differences between the two groups[MD=-0.24,95%CI=-0.88~0.39,P=0.46].Agomelatine group was superior to escitalopram group in side effects[OR=0.56,95%CI=0.45~0.69,P<0.00001,I2=64%]. Conclusion The efficacy of agomelatine and escitalopram in the treatment of depression wss similar, and the safety was generally acceptable.
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