| objective to observe the diagnostic value and correlation of respiratory virus, inflammatory cytokines and lung function in acute exacerbation of chronic obstructive pulmonary disease (copd). Methods in November 2017 - November 2019 admitted in our hospital of chronic obstructive pulmonary disease in patients with acute aggravating period, a total of 102 cases as the research object, through collecting the sputum of patients and analyze its sputum respiratory virus detection, according to the results it can be divided into positive group (n = 39) and virus negative group (n = 63), the contrast between the virus positive group and negative group of respiratory viruses, inflammatory cytokine, the difference of pulmonary function, and observe the respiratory virus, inflammatory cytokine, the correlation between the lung function. Results according to the virus test results, the 102 patients were divided into 39 cases in the virus positive group and 63 cases in the virus negative group. There were no significant differences in age, gender, smoking, body weight, ICS use, hypertension, coronary heart disease, arrhythmia, mMRC score, white blood cell count, neutrophil count, eosinophil ratio, alanine aminotransferase, serum creatinine and CD4+ cell ratio between the two groups (P >, 0.05). There were significant differences in hospital stay, diabetes, pulmonary function indicators (FEV1/FVC, FEV 1%), fever, CAT score and CD8+ cell ratio between the two groups (P < 0.05), and significantly increased in the virus-positive group, while decreased in pulmonary function indicators (FEV1/FVC, FEV 1%) and CD8+ cell ratio. Virus positive and virus negative group of IL - 6, IL - 8, IP - 10, RANTES, sIL - 2 r, TNF alpha and c-reactive protein, compared significant difference (P ﹤ 0.05), the virus positive group of IL - 6, IL - 8, IP - 10, RANTES, sIL 2 r, interferon gamma, TNF alpha and c-reactive protein were higher than in virus negative group, compared two groups of interferon - gamma, there was no statistically significant difference (P > 0.05). The il-6, ip-10, sil-2r, TNF- serum and c-reactive protein levels of the virus negative group were significantly different from those of influenza virus type A and rhinovirus positive group (P < 0.05). The il-6, ip-10, sil-2r and c-reactive protein levels of influenza virus type A were significantly increased, while the il-8, interferon - antibody and TNF- serum levels of rhinovirus positive group were significantly increased. FEV 1, FEV 1/FVC, diabetes, fever, CAT score, CD4+ cell ratio, ip-10, sIL-2R, TNF- levels were negatively correlated with virus positivity (r =-0.452, -0.552, -12.987, -0.672, -0.563, -0.872, -0.982, -0.972, -7.372, P < 0.001). Conclusion respiratory tract viruses and inflammatory cytokines are common in acute exacerbation of chronic obstructive pulmonary disease (copd), and they are closely correlated with decreased lung function, which can be used as a diagnostic basis for judging the acute exacerbation of copd. |
