欢迎访问浙江中西医结合杂志   今天是   加入收藏   |   设为首页
李良飞,金永军,张秀峰,沈忠.肛周脓肿和肛瘘组织TNF-α、IL-4的表达和意义[J].浙江中西医结合杂志,2020,30(7):
肛周脓肿和肛瘘组织TNF-α、IL-4的表达和意义
Expression and significance of TNF-α and IL-4 in perianal abscess and anal fistula
投稿时间:2020-01-18  修订日期:2020-03-15
DOI:
中文关键词:  肛周脓肿  肛瘘  免疫组化  肿瘤坏死因子-α  白细胞介素-4
英文关键词:Perianal abscess  Anal fistula  Immunohistochemical  TNF-α  IL-4
基金项目:杭州市卫生科技计划一般项目(No.2017A26)
作者单位E-mail
李良飞 杭州市红十字会医院 liliangfei159@163.com 
金永军 杭州市红十字会医院肛肠外科  
张秀峰 杭州市第三人民医院肛肠外科  
沈忠 杭州市第三人民医院肛肠外科 shenzhong114@sina.com 
摘要点击次数: 80
全文下载次数: 0
中文摘要:
      目的 研究TNF-α、IL-4在肛周脓肿和肛瘘组织中的表达及意义。方法 回顾性分析120例首发肛周脓肿或肛瘘的患者资料,应用免疫组织化学染色法对脓肿壁和瘘管病理标本中TNF-α、IL-4的表达进行检测,并分析TNF-α、IL-4表达的相关性。结果 TNF-α的表达阳性率在肛周脓肿组、肛瘘病程<3月组、肛瘘病程3~6月组、肛瘘病程>6月组分别为80%、90%、83%、73%,阳性率比较差异有统计学意义(P<0.05);各组中IL-4的表达阳性率分别为70%、83%、63%、50%,阳性率比较差异有统计学意义(P<0.05),且TNF-α、IL-4的表达呈正相关(rs=0.707,P<0.05)。结论 TNF-α和IL-4在肛周脓肿、肛瘘炎症反应中具有较高的阳性率表达,且TNF-α和IL-4在不同病程时期的表达呈正相关,提示TNF-α、IL-4参与肛周脓肿及肛瘘的发生及发展。
英文摘要:
      ABSTRACT Objective To investigate the significance and expression of TNF-α and IL-4 in the perianal abscess and anal fistula. Methods Clinical data of 120 patients with first-episode perianal abscess or anal fistula were analyzed retrospectively. The expression of TNF-α and IL-4 were detected by Immunohistochemical staining on the pathological specimens of abscess wall and fistula, and the correlation between TNF-α and IL-4 expression was analyzed. Results In the perianal abscess group, anal fistula course<3 months group, anal fistula course 3~6 months group, and anal fistula course>6 months group, the positive rates of TNF-α expression were 80%, 90%, 83%, 73% respectively. The difference of expression rate was statistically significant (P<0.05); The positive rate of IL-4 expression in each group was 70%, 83%, 63% and 50%, respectively, The difference of expression rate was statistically significant (P<0.05), and the expressions of TNF-α and IL-4 were positively correlated(rs=0.707,P<0.05). Conclusion TNF-α and IL-4 had higher positive expression rates in the inflammatory response of perianal abscesses and anal fistula. Moreover, the expression of TNF-α and IL-4 in different disease stages was positively correlated , suggesting that TNF-α and IL-4 are involved in the occurrence and development of perianal abscess and anal fistula.
查看全文  查看/发表评论  下载PDF阅读器
关闭