| 周毅,王晗,陈晓娟,舒贤周,林希.痛泄要方加味结合艾灸治疗腹泻型肠易激综合征的疗效评价和机制研究[J].浙江中西医结合杂志,2020,30(9): |
| 痛泄要方加味结合艾灸治疗腹泻型肠易激综合征的疗效评价和机制研究 |
| Efficacy Evaluation and Mechanism Study on the Treatment of Diarrhea-Irritable Bowel Syndrome with Traditional Chinese Medicine Combined with Moxibustion |
| 投稿时间：2019-12-27 修订日期：2020-06-27 |
| DOI： |
| 中文关键词: 痛泄要方加味 艾灸 肠易激综合征 腹泻型 |
| 英文关键词:traditional Chinese Medicine moxibustion Diarrhea type Irritable Bowel Syndrome |
| 基金项目:基金项目证明文件 |
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| 中文摘要: |
| 目的 观察中药汤剂痛泄要方加味结合艾灸治疗腹泻型肝气乘脾证肠易激综合征(IBS)的疗效,及其作用机制。方法 将120例腹泻型肝气乘脾证肠易激综合征患者,采用随机数字表法分为观察组和对照组,每组60例。观察组给予中药汤剂痛泄要方加味,每日1剂,水煎400mL,早、晚分服,并结合神阙穴隔药灸,1次/2d,30min/次；对照组给予双歧杆菌三联活菌散(培菲康)2.0g,3次/d,口服治疗。以上两组治疗方案疗程均为4周。观察评估两组治疗前、治疗2周和治疗4周后IBS病情严重程度调查表、IBS大便性状问卷、中医证候疗效,以及粪便球杆比、肠道双歧杆菌/大肠杆菌(B/E)比值的变化。结果 治疗2周、4周后,观察组总体疗效、大便情况、中医证候疗效均优于对照组(P<0.05,P<0.01),两组粪便杆菌比例、双歧杆菌含量及B/E值与治疗前比较均呈逐渐上升趋势(P<0.05,P<0.01)且观察组显著高于对照组(P<0.05)。结论 中药汤剂痛泄要方加味结合艾灸应用于腹泻型肝气乘脾证肠易激综合征能有效调节肠道菌群,缓解肠道症状,改善大便性状和肝气乘脾证候,在临床治疗上有一定的优势。 |
| 英文摘要: |
| Objective：To observe the curative effect and the mechanism of the treatment of Diarrhea-Irritable Bowel Syndrome of liver Qi multiplying spleen with traditional Chinese Medicine combined with moxibustion. Methods：A total of 120 patients with Diarrhea-Irritable Bowel Syndrome of liver Qi multiplying spleen were divided by random number table into the observation group and the control group with 60 cases respectively. The observation group was treated with traditional Chinese medicine decoction called modified Tongxie Yaofang (one dose a day, water decocted 400mL, drink once in the morning and evening) combined with herbs-partition moxibustion at Shenque point (Once every 2 days, once every 30 minutes), and the control group was treated with oral Bifidobacterium triple viable powder (once 2.0g, 3 times a day), both for 4 weeks. The IBS symptom severity scale, the IBS defecation state questionnaire, the traditional Chinese medicine pattern curative effect scoring system,the ratio of fecal cocci to bacilli, the Ratio of bifidobacteria to Escherichia coli (B/E) before treatment, 2 weeks after treatment and 4 weeks after treatment were observed and evaluated. Results：After 2 and 4 weeks of treatment, The overall effect, defecation and TCM syndrome effect of the observation group were better than those of the control group(P<0.05,P<0.01), and compared with those before treatment, the proportion of fecal bacilli, the content of bifidobacteria and the B/E value of the two groups increased gradually after treatment(P<0.05,P<0.01), furthermore, the above indicators in the observation group were remarkably higher than those of the control group(P<0.05). Conclusion：It has certain advantages in clinical treatment to use traditional Chinese Medicine decoction called modified Tongxie Yaofang combined with moxibustion in the treatment of Diarrhea-Irritable Bowel Syndrome of liver Qi multiplying spleen to effectively regulate the intestinal flora, relieve the intestinal symptoms, improve the stool characteristics and the syndrome of liver Qi multiplying spleen. |
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