| 金光军,张建成,盛洋,叶柏春,周冰之.血府逐瘀汤加味对急性心肌梗死PCI术后患者的临床疗效研究[J].浙江中西医结合杂志,2020,30(9): |
| 血府逐瘀汤加味对急性心肌梗死PCI术后患者的临床疗效研究 |
| Clinical Effect of Xuefu Zhuyu Decoction in Patients with Acute Myocardial Infarction after Percutaneous Coronary Intervention |
| 投稿时间：2019-12-22 修订日期：2020-06-23 |
| DOI： |
| 中文关键词: 急性心肌梗死 经皮冠状动脉介入术 血府逐瘀汤 血管新生 |
| 英文关键词:Acute myocardial infarction Percutaneous coronary intervention Xuefu Zhuyu Decoction angiogenesis. |
| 基金项目:浙江省中医药科技计划项目(2019ZB053) |
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| 中文摘要: |
| 目的：探讨血府逐瘀汤加味对急性心肌梗死PCI术后患者的临床疗效及机制。方法：选取急性心肌梗死PCI术后患者126例,随机分为对照组和研究组。对照组患者给予常规西医治疗；治疗组患者在对照组治疗的基础上,加用血府逐瘀汤加味。治疗4周后,观察两组临床疗效、血清学指标、心脏彩超、再狭窄率及不良反应发生情况。结果：研究组治疗总有效率高于对照组,差异具有统计学意义(p<0.05)。两组患者术前VEGF、bFGF和TGF-β1进行比较,差异无统计学意义(p>0.05)；研究组患者术后1周与术后4周的VEGF、bFGF和TGF-β1均较对照组升高,差异具有统计学意义(p<0.05)；与术前相比,两组患者术后1周与术后4周的VEGF、bFGF和TGF-β1均升高,且术后4周更为明显,差异具有统计学意义(p<0.05)。术后4周两组患者的LVEDD、LVESD较术前降低,LVEF较术前升高,差异具有统计学意义(p<0.05)；且研究组术后4周的LVESD、LVEDD较对照组降低、LVEF较对照组升高,差异具有统计学意义(p<0.05)。两组患者PCI术后,对照组患者发生再狭窄17例,研究组患者发生再狭窄8例,两组差异具有统计学意义(p<0.05)。两组患者的不良反应差异无统计学意义(p>0.05)。结论：血府逐瘀汤加味可以有效改善急性心肌梗死PCI术后患者的心功能,改善心室重塑,促进血管新生,降低再狭窄率,提高临床疗效,且无明显不良反应,值得临床推广。 |
| 英文摘要: |
| Objective: To investigate the clinical effect and mechanism of Xuefu Zhuyu Decoction in patients with acute myocardial infarction after PCI. Methods: 126 patients with AMI after PCI were randomly divided into control group and study group. Patients in the control group were given conventional western medicine treatment.On the basis of the treatment of the control group, the patients in the study group were given Xuefu Zhuyu Decoction. After 4 weeks of treatment, the clinical efficacy, serological indicators, echocardiography, restenosis rate and adverse reactions of the two groups were observed. Results: The total effective rate in the study group was higher than that in the control group, and the difference was statistically significant (p<0.05). Preoperative comparison of VEGF, bFGF and TGF-β1 in the two groups showed no statistically significant difference (p>0.05).VEGF, bFGF and TGF-β1 in the study group were significantly higher than those in the control group at 1 week and 4 weeks after PCI(p<0.05).Compared with the preoperative level, VEGF, bFGF and TGF-β1 were increased in both groups at 1 week and 4 weeks after PCI, and the difference was more significant at 4 weeks (p<0.05).4 weeks after PCI, LVEDD and LVESD in the two groups were lower, while LVEF was higher, with statistically significant differences(p<0.05).In addition, LVESD and LVEDD in the study group were decreased and LVEF was increased compared with the control group at 4 weeks after PCI, with statistically significant differences (p<0.05).After PCI, restenosis occurred in 17 patients in the control group and 8 patients in the study group, with statistically significant difference (p<0.05).There was no significant difference in adverse reactions between the two groups (p>0.05). Conclusion: Xuefu Zhuyu Decoction can effectively improve the cardiac function of patients with acute myocardial infarction after PCI, improve ventricular remodeling, promote angiogenesis, reduce the rate of restenosis, and improve the clinical effect. With no obvious adverse reactions, it is worthy of clinical promotion. |
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