| 作者：戚敏敏,曾武城,王敏磊,应航宇,邬成霖.邬氏脱发方对雄激素性秃发的毛发生长周期及血液流变学的影响[J].浙江中西医结合杂志,2020,30(7): |
| 邬氏脱发方对雄激素性秃发的毛发生长周期及血液流变学的影响 |
| Effect of Wu |
| 投稿时间：2019-12-18 修订日期：2020-03-27 |
| DOI： |
| 中文关键词: 雄激素性秃发,邬氏脱发方,非那雄胺,毛发周期,血粘度 |
| 英文关键词:Androgenetic alopecia, Wu's alopecia decoction, Finasteride, hair cycle, Hemarheology |
| 基金项目:杭州市科技发展计划 |
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| 中文摘要: |
| 目的：观察邬氏脱发方对雄激素性秃发的毛发生长周期及血液流变学的影响。方法：180例AGA患者随机分为三组，西药组予非那雄胺片口服，中药组予邬氏脱发方口服，联合组予邬氏脱发方联合非那雄胺片口服。观察比较治疗前后患者生长期头发计数情况及血黏度、红细胞压积、血沉的变化，同时评估临床疗效。结果：联合组生长期头发增量计数明显高于西药组和中药组，差异有统计学意义（P<0.05），西药组与中药组比较，差异无统计学意义（P>0.05），。中药组、联合组全血黏度高切指数水平治疗后较治疗前明显下降，差异有统计学意义（P<0.05），西药组治疗前后比较差异无统计学意义（P>0.05）。全血低切指数、中切指数、血浆粘度、Hct、ESR三组治疗前后比较无明显差异（P>0.05）。联合组总有效率（100%）明显优于西药组（74.1%）、中药组（77.8%），差异有统计学意义（P<0.05）。结论：邬氏脱发方治疗雄激素性秃发可能是通过对毛发周期和血液流变学的改变达到治疗雄激素性秃发的目的，且邬氏脱发方联合非那雄胺治疗雄激素性发疗效更佳。 |
| 英文摘要: |
| Objective: To observe the effect of Wu's alopecia decoction on hair cycle and Hemarheology of Androgenetic alopecia. Methods: 180 AGA patients were randomly divided into three groups: the tablet group was given Finasteride tablet orally, the TCM group was given Wu's alopecia decoction orally, and the combined group was given Wu’s alopecia decoction and Finasteride tablet orally. To observe and compare the changes of the growing hair count, blood viscosity, Hct and ESR before and after the treatment, and to evaluate the clinical efficacy. Results: The hair increment count in the growing period of the combined group was significantly higher than that of the tablet group and the TCM group(P<0.05). while the tablet group and the TCM group was not statistically significant (P>0.05). After treatment, the blood viscosities at a high shear of the TCM group and the combined group was significantly lower than that before treatment (P<0.05), while there was no statistically significant difference before and after treatment in the tablet group (P>0.05). There was no significant difference between the three groups before and after treatment in blood viscosities at a low/middle shear rate, plasma viscosity, Hct and ESR (P>0.05). The total effective rate of the combined group (100%) was significantly better than that of the western medicine group (74.1%) and the traditional Chinese medicine group (77.8%)（P<0.05）.Conclusion: the treatment of Androgenetic alopecia by Wu's alopecia decoction may be achieved through the change of hair cycle and hemorheology, and the treatment of androgenetic alopecia by Wu's alopecia decoction combined with Finasteride is more effective. |
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