| 陈丽丹.前列腺素E1联合连续肾替代治疗对脓毒症合并急性肾损伤预后的影响[J].浙江中西医结合杂志,2020,30(8): |
| 前列腺素E1联合连续肾替代治疗对脓毒症合并急性肾损伤预后的影响 |
| The effect of prostaglandin E1 combined with continuous renal replacement therapy on the prognosis of sepsis with acute renal injury |
| 投稿时间：2019-11-08 修订日期：2020-03-28 |
| DOI： |
| 中文关键词: 前列腺素E 连续肾替代 脓毒症 急性肾损伤 预后 |
| 英文关键词:prostaglandin E continuous renal replacement sepsis acute renal injury prognosis |
| 基金项目: |
|
| 摘要点击次数: 551 |
| 全文下载次数: 6 |
| 中文摘要: |
| 目的：探讨分析前列腺素E1联合连续肾替代治疗对脓毒症合并急性肾损伤患者临床预后的影响。方法：选择2017年3月~2019年3月我院收治的脓毒症合并急性肾损伤患者92例,随机分为观察组48例、对照组44例,对照组患者在常规治疗基础上给予连续性肾脏替代疗法,观察组在对照组基础上给予前列腺素E1。比较两组患者急性生理与慢性健康II(APACHE II)评分、肾功能指标、血清炎症因子、多器官功能障碍综合征(MODS)发生率以及患者28d死亡率。结果：治疗3d、治疗7d两组患者APACHE II评分均较治疗前显著降低(P<0.05),且治疗7d观察组患者低于对照组(P<0.05)。治疗7d两组患者肾功能指标BUN、Scr均较治疗前显著降低(P<0.05),且治疗7d观察组患者BUN、SCr明显低于对照组(P<0.05)。治疗7d两组患者炎症因子指标IL-6、IL-10、TNF-α均较治疗前显著降低(P<0.05),且治疗7d观察组低于对照组(P<0.05)。观察组患者MODS发生率明显低于对照组(P<0.05),两组患者28d死亡率无明显差异(P>0.05)。结论：前列腺素E1联合连续性肾替代疗法治疗脓毒症并发急性肾损伤患者,可有效改善机体肾功能、减轻机体炎症反应,从而有助于改善患者病情及临床预后,值得临床推广。 |
| 英文摘要: |
| Objective: To investigate the effect of prostaglandin E1 combined with continuous renal replacement therapy on the clinical prognosis of sepsis patients with acute renal injury. Methods: 92 patients with sepsis and acute renal injury admitted to our hospital from March 2017 to March 2019 were randomly divided into observation group (48 cases) and control group (44 cases). Patients in the control group were given continuous renal replacement therapy on the basis of conventional treatment, while those in the observation group were given prostaglandin E1 on the basis of the control group. The acute physiological and chronic health II (APACHE II) score, renal function index (SCr, BUN), serum inflammatory factors (IL-6, IL-10, TNF-α), incidence of multiple organ dysfunction syndrome (MODS) and 28 day mortality rate were compared between the two groups. Results: the APACHE II score of the two groups was significantly lower than that before treatment (P<0.05), and the APACHE II score of the observation group was significantly lower than that of the control group (P<0.05). On the 7th day of treatment, the renal function indexes bun and SCR in the two groups were significantly lower than those before treatment (P<0.05), and BUN and SCR in the observation group were significantly lower than those in the control group (P<0.05). IL-6, IL-10 and TNF-α in the two groups were significantly lower than those before treatment (P<0.05), and IL-6, IL-10 and TNF-α in the observation group were significantly lower than those in the control group (P<0.05). The incidence of MODS in the observation group was significantly lower than that in the control group (P<0.05), and there was no significant difference in 28 day mortality between the two groups (P>0.05). Conclusion: prostaglandin E1 combined with continuous renal replacement therapy can effectively improve renal function and reduce inflammatory response in patients with sepsis complicated with acute renal injury, which is helpful to improve patients" condition and clinical prognosis, and is worthy of clinical promotion. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
