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冀小波,毛敏杰,黄晓庆,徐节坤,潘晓鸿,潘蕾,邱君克,汪彩红.重症肺结核合并肺曲霉菌病患者免疫水平的回顾性分析[J].浙江中西医结合杂志,2020,30(7):
重症肺结核合并肺曲霉菌病患者免疫水平的回顾性分析
Retrospective analysis of immune level in severe tuberculosis patients with Pulmonary aspergillosis
投稿时间:2019-10-31  修订日期:2020-04-03
DOI:
中文关键词:  重症肺结核  肺曲霉菌病  免疫水平
英文关键词:severe tuberculosis patients  pulmonary aspergillosis  the immune level
基金项目:杭州市科委项目(20191203B127)
作者单位E-mail
冀小波 杭州市红十字会医院 jixiaobo90@163.com 
毛敏杰 杭州市红十字会医院  
黄晓庆 杭州市红十字会医院  
徐节坤 杭州市红十字会医院  
潘晓鸿 杭州市红十字会医院  
潘蕾 杭州市红十字会医院  
邱君克 杭州市红十字会医院  
汪彩红 杭州市红十字会医院 3160129890@qq.com 
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中文摘要:
      【摘要】目的:分析重症肺结核合并肺曲霉菌病患者的免疫水平,以期为临床诊治提供参考价值。方法:选取2009年1月-2019年9月在浙江省中西医结合医院·结核病诊疗中心·结核监护室住院治疗的重症肺结核合并肺曲霉菌病患者30例作为试验组,同时随机选择同期不合并肺曲霉菌病的重症肺结核患者40例作为对照组;共计70例患者。对所有研究对象进行外周血中T细胞(CD3+细胞、CD4+细胞、CD8+细胞、CD4/CD8)、B细胞[总B细胞、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、补体3(C3)、补体4(C4)]、自然杀伤(natural killer,NK)细胞等指标的检测,对试验组和对照组上述指标进行对比分析。结果:重症肺结核合并肺曲霉菌病的患者外周血中IgA、IgM、C4、总B细胞、CD4+细胞、CD4/CD8水平较未合并肺曲霉菌病的种子肺结核患者明显下降,CD8+细胞水平明显升高。结论:重症肺结核合并肺曲霉菌病患者相对于重症肺结核患者具有更差的免疫水平,提示在临床工作中可以对重症肺结核患者的免疫状况进行干预以减少肺曲霉菌病的发病率,有助于肺结核的防治。
英文摘要:
      Abstract: Objective: The immune level of severe tuberculosis patients with pulmonary aspergillosis was analyzed in order to provide reference for clinical diagnosis and treatment. Methods: From January 2009 to September 2019, 30 severe tuberculosis patients with pulmonary aspergillosis were selected as the experimental group, while 40 severe tuberculosis patients without pulmonary aspergillus disease were randomly selected as the control group. A total of 70 patients. T cells(CD3 + cells , CD4 + cells, CD8 + cells and CD4 / CD8), B cells[B cells, immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), complement 3 (C3) and complement 4 (C4)], Natural killer cells and so on in peripheral blood of all patients were tested, and the above indicators in the experimental group and the control group were compared and analyzed. Results: The levels of IgA, IgM, C4, total B cells, CD4+ cells and CD4/CD8 in peripheral blood of severe tuberculosis patients with pulmonary aspergillosis were significantly lower than those of patients without pulmonary aspergillosis, while the levels of CD8+ cells were Obviously higher. Conclusion: severe tuberculosis patients with pulmonary aspergillosis have poorer immune level than those without pulmonary aspergillosis, which suggests that the immune status of patients with severe pulmonary tuberculosis can be intervened in clinical work to reduce the incidence of pulmonary aspergillosis, which is conducive to the prevention and treatment of pulmonary tuberculosis.
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