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涂俊才,周平,楼莲青.血必净对乙型肝炎慢加急性肝功能衰竭早期患者炎症因子、肝功能及凝血功能的影响[J].浙江中西医结合杂志,2020,30(5):
血必净对乙型肝炎慢加急性肝功能衰竭早期患者炎症因子、肝功能及凝血功能的影响
Effects of Xuebijing injection on serum inflammatory cytokines and Liver function ,coagulation parameters in patients with early stage of HBV-related acute-on-chronic liver failureTu Jun-Cai1, Zhou Ping2 , Lou Lian-Qing 1
投稿时间:2019-10-10  修订日期:2020-01-07
DOI:
中文关键词:  血必净注射液  慢加急性肝衰竭  炎症因子  内毒素  肝功能  凝血功能
英文关键词:Xuebijing injection  Acute-on-chronic liver  Inflammatory cytokine  Endotoxin  Liver function  Blood coagulation function
基金项目:
作者单位E-mail
涂俊才 浙江省义乌市中心医院感染科 浙江省义乌市 18267973375@163.com 
周平 北京市中国人民解放军空军总医院感染科 北京市海淀区  
楼莲青 浙江省义乌市中心医院感染科 浙江省义乌市 18267973375@163.com 
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中文摘要:
      目的 探究血必净注射液对乙型肝炎慢加急性肝功能衰竭早期患者炎症因子、肝功能及凝血功能的影响。方法 选取中国人民解放军空军总医院感染科2013年6月—2015年4月收治的78例乙型肝炎慢加急性肝衰竭早期患者,随机分为对照组和研究组。对照组39例,采用内科常规综合治疗;研究组39例,在内科常规综合治疗基础上加用血必净注射液。治疗7天后,检测两组患者治疗前后的血清中炎症因子TNF-α、IL-6、IL-1、IL-10及内毒素LPS的水平,同时检测两组患者治疗前后的肝功能:TBIL、ALT、AST及凝血功能:凝血酶原时间(PT)、部分凝血酶原时间(APTT)、凝血酶原活动度(PTA)、D-二聚体(D-D)、血小板(PLT)计数。结果 观察组患者治疗后血清中TNF-α、IL-6、IL-1、LPS低于对照组, 而血清中的IL-10的水平则明显高于对照组(P均<0.05)。 治疗后对照组和研究组TBIL、ALT、AST及PT、APTT、PTA、D-D、PLT 计数均较治疗前得到改善(P均<0.05),其中研究组中各指标均显著优于对照组(P均<0.05)。 结论 血必净联合常规内科综合治疗能降低乙型肝炎慢加急性肝衰竭早期患者的炎症反应, 同时能改善患者的肝功能及凝血功能。
英文摘要:
      AIM To observe effects of Xuebijing injection on serum inflammatory cytokines and Liver function,coagulation parameters in patients with early stage of HBV-related acute-on-chronic liver failure. METHODS During April 2013 toJuneS2015 at department of infectious diseases, Air Force General Hospital. 78 patients with early stage of HBV-related acute-on-chronic liver were randomly divided into control and observation groups (n = 39 each).The control group received the conventionally comprehensive treatment while the observation group had a combination of Xuebijing injection and the conventionally comprehensive treatmente.The therapeutic course for all was 1 wk,the levels of serum infl ammatory factors(TNF-α、IL-6、IL-1、IL-10) and endotoxin(LPS) were compared between the two groups. And the Liver function(TBIL、ALT、AST)and coagulation parameters (PT、APTT、PTA、D-D、PLT) were compared. RESULTS (1)By the end of the treatment ,in the observation group, the serum levels of TNF-α、IL-6、IL-1 and LPS were lower than those of the control group, while the level of IL-10 in serum was significantly higher than that in control group (P < 0.05).(2) The TBIL、ALT、AST in the observation group were lower significantly than those in the control group(P < 0.05).(3) The changes of blood coagulation,including PT, APTT, FIB, PTA, D-D and PLT count after treatment in the two groups were significantly improved compared with those before treatment(P < 0.05), and the indexes improvement in observation group were superior to that in the control group(P < 0.05).CONCLUSION Xuebijing can alleviate inflammatory reaction with few adverse reaction in early stage of HBV-related acute-on-chronic liver failure., And improve the Liver function,blood coagulation function.
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