| 张兰英.艾司西酞普兰联合认知行为治疗对广泛性焦虑障碍患者的临床研究及生活质量观察[J].浙江中西医结合杂志,2020,30(4): |
| 艾司西酞普兰联合认知行为治疗对广泛性焦虑障碍患者的临床研究及生活质量观察 |
| Clinical study of escitalopram combined with cognitive behavioral therapy in patients with generalized anxiety disorderZhang Lanying ,Shi Po ,Zhang Jin,Lan Jianping, Department of Psychiatry, Jinhua Second Hospital, Zhejiang Province, 321000 |
| 投稿时间：2019-09-26 修订日期：2019-12-15 |
| DOI： |
| 中文关键词: 艾司西酞普兰 认知行为治疗 广泛性焦虑障碍 |
| 英文关键词:escitalopram cognitive behavioral therapy generalized anxiety disorder |
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| 中文摘要: |
| 目的：探讨艾司西酞普兰联合认知行为治疗对广泛性焦虑障碍患者临床研究。方法：选择我院于2017年5月至2019年5月期间收治的广泛性焦虑障碍患者98例,采用随机数字表法随机分为对照组49例与观察组49例。对照组患者采用认知行为治疗,观察组患者在对照组基础上结合艾司西酞普兰治疗。两组疗程均为8周。比较两组治疗疗效,治疗前后汉密尔顿焦虑量表(HAMA)和焦虑自评量表(SAS)评分、功能大体评定量表(GAF)评分和生活质量量表(QOL)评分变化。结果：观察组总有效率(93.88%)高于对照组(71.43%)(P<0.05)。两组治疗后HAMA评分和SAS评分较治疗前降低(观察组：t=41.805、22.382,对照组：t=29.026、20.225,P<0.05)；观察组治疗后HAMA评分和SAS评分低于对照组(t=12.441、7.897,P<0.05)。两组治疗后GAF评分较治疗前增加(观察组：t=33.597,对照组：t=16.166,P<0.05)；观察组治疗后GAF评分高于对照组(t=10.880,P<0.05)。两组治疗后QOL量表评分较治疗前增加(观察组：t=11.249、16.045、11.758、12.823,对照组：t=10.228、10.627、7.176、7.051,P<0.05)；观察组治疗后QOL量表评分高于对照组(t=7.258、6.896、5.616、4.739,P<0.05)。结论：艾司西酞普兰联合认知行为治疗对广泛性焦虑障碍患者临床疗效良好,可明显减轻患者焦虑障碍,且可改善患者生活质量,值得临床借鉴。 |
| 英文摘要: |
| Objective: To investigate the clinical effect of escitalopram combined with cognitive behavioral therapy on patients with generalized anxiety disorder. Methods: The 98 patients with generalized anxiety disorder admitted to our hospital from May 2017 to May 2019 were randomly divided into control group (49 cases) and observation group (49 cases). Patients in the control group were treated with cognitive behavioral therapy, while patients in the observation group were treated with escitalopram on the basis of the control group. Both groups were treated for 8 weeks. The therapeutic effects of the two groups were compared. The changes of Hamilton Anxiety Scale (HAMA), Self-rating Anxiety Scale (SAS), General Functional Assessment Scale (GAF) and Quality of Life Scale (QOL) before and after treatment were compared. Results: The total effective rate of the observation group (93.88%) was higher than that of the control group (71.43%) (P<0.05). After treatment, HAMA and SAS scores in the two groups were lower than those before treatment (observation group:t=41.805, 22.382, control group:t=29.026, 20.225, P<0.05); after treatment, HAMA and SAS scores in the observation group were lower than those in the control group (t=12.441, 7.897, P<0.05). After treatment, the GAF score of the two groups was higher than that of the control group (observation group:t=33.597, control group:t=16.166, P<0.05); after treatment, the GAF score of the observation group was higher than that of the control group (t=10.880, P<0.05). The scores of QOL scale in the two groups increased after treatment (observation group:t=11.249, 16.045, 11.758, 12.823, control group:t=10.228, 10.627, 7.176, 7.051, P<0.05); after treatment, the scores of QOL scale in the observation group were higher than those in the control group (t=7.258, 6.896, 5.616, 4.739, P<0.05). Conclusion: Escitalopram combined with cognitive behavioral therapy has a good clinical effect on patients with generalized anxiety disorder, can significantly reduce anxiety disorder, and can improve the quality of life of patients, which is worthy of clinical reference. |
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