欢迎访问浙江中西医结合杂志   今天是   加入收藏   |   设为首页
何君婷,龚文波.TNF-α、IL-1β、IL-6炎症因?在2型糖尿病的中医证型中的表达差异性[J].浙江中西医结合杂志,2020,30(5):
TNF-α、IL-1β、IL-6炎症因?在2型糖尿病的中医证型中的表达差异性
Differential expression of inflammatory factors TNF-α ,IL-1β,IL-6 in TCM Syndromes of type2 Diabetes mellitus
投稿时间:2019-07-10  修订日期:2020-04-21
DOI:
中文关键词:  2型糖尿病  肿瘤坏死因子α  ?细胞介素1β  ?细胞介素-6  气阴两虚证  气虚证  阴虚证
英文关键词:Type 2 diabetes mellitus  Tumor necrosis factor-α  Interleukin-1 beta  Interleukin-6  Qi-Yin deficiency syndrome  Qi deficiency syndromeYin deficiency syndrome.
基金项目:2016年度浙江省中医药科学研究基金项目
作者单位E-mail
何君婷 宁波市中医院内分泌科 邮编315000 20404199@qq.com 
龚文波 宁波市中医院内分泌科 邮编315000 gongwenbo@126.com 
摘要点击次数: 50
全文下载次数: 0
中文摘要:
      目的 探究肿瘤坏死因子α(TNF-α)、?细胞介素1β(IL-1β)、?细胞介素-6(IL-6)炎症因?在?虚、阴虚、?阴两虚2型糖尿病中的表达差异性。方法 临床随机抽取T2DM患者202例为观察组,按照中医辨证分为气虚组、阴虚组、气阴两虚组,正常体检人员73例为对照组。检测各组研究对象外周?中TNF-α、IL-1β、IL-6、C-反应蛋?(hs-CRP)、空腹?糖(FPG)和糖化?红蛋??平(HbA1c)。结果 气阴两虚组、气虚组、阴虚组hs-CRP、FPG、HbA1c均明显高于对照组(P<0.05);气阴两虚组TNF-α、IL-1β、IL-6均明显高于对照组,气虚组,阴虚组 (P<0.05);气虚组、阴虚组患者TNF-α、IL-1β、IL-6水平与对照组比较差异无统计学意义(P>0.05)。结论2型糖尿病患者中的TNF-α、IL-1β、IL-6的?平在?虚、阴虚和?阴两虚中具有差异性,可以作为2型糖尿病的中医辩证的客观指标?于临床实践中。
英文摘要:
      Objective To explore the differential expression of inflammatory factors TNF-α ,IL-1β,IL-6 in T2DM with Qi deficiency syndrome,Yin deficiency syndrome and Qi-Yin deficiency syndrome.Methods A total of 202 patients with T2DM were randomly selected as observation group. According to TCM syndrome differentiation, they were divided into Qi deficiency syndrome group, Yin deficiency syndrome group and Qi-yin deficiency syndrome group. 73 normal physical examination personnel were used as control group. The levels of TNF-α ,IL-1β,IL-6, hs-CRP,fasting blood glucose and glycosylated hemoglobin in peripheral blood were examined.Results The levels of hs-CRP,fasting blood glucose and glycosylated hemoglobin in Qi deficiency syndrome group,Yin deficiency syndrome group and Qi-Yin deficiency syndrome group were significantly higher than those in the control group (P<0.05). The TNF-α, IL-1β and IL-6 levels in the Qi-Yin deficiency syndrome group were significantly higher than those in the control group, Qi deficiency syndrome group and Yin deficiency syndrome group (P<0.05).There were no significant differences in levels of TNF-α ,IL-1β,IL-6 between Qi deficiency syndrome group ,Yin deficiency syndrome group and control group(P>0.05). Conclusions The levels of TNF-α, IL-1β and IL-6 in blood are different in T2DM with Qi deficiency syndrome ,Yin deficiency syndrome and Qi-Yin deficiency syndrome.They can be used as an objective indicator of TCM dialectical diagnosis of T2DM in clinical practice.
查看全文  查看/发表评论  下载PDF阅读器
关闭