| 王琴晓,林希,水旭娟,徐琦,陈海迎,陈雪,杨思思.参芪增液活血汤联合补液治疗对妊娠晚期羊水偏少孕妇超声指标分析及妊娠结局的影响[J].浙江中西医结合杂志,2019,29(12): |
| 参芪增液活血汤联合补液治疗对妊娠晚期羊水偏少孕妇超声指标分析及妊娠结局的影响 |
| Effect of Shenqi Zengye Huoxue Decoction combined with rehydration on ultrasonographic indexes and pregnancy outcome of pregnant women with oligohydramnios in late pregnancy |
| 投稿时间：2019-06-13 修订日期：2019-09-23 |
| DOI： |
| 中文关键词: 参芪增液活血汤 羊水偏少 羊水指数 超声 胎儿窘迫 |
| 英文关键词:Shenqi Zengye Huoxue Decoction Oligohydramnios Amniotic fluid index Ultrasound Fetal distress |
| 基金项目:] 温州市医药卫生科研项目(编号2016ZA02) |
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| 中文摘要: |
| 目的：评估参芪增液活血汤结合补液治疗对妊娠晚期羊水偏少孕妇超声指标分析及妊娠结局的影响。方法：使用随机平行对照方法,将符合纳入标准的91例妊娠晚期羊水偏少患者分为治疗组和对照组,对照组46例,治疗组45例,对照组给予补液治疗,治疗组在对照组的基础上加用参芪增液活血汤口服治疗,连续治疗7d为一疗程,通过超声比较观察两组羊水指数、脐动脉收缩期最大血流速度/舒张期末血流速度(S/D),胎儿生物物理评分指标,并比较两组妊娠结局差异。结果：两组治疗后AFI值均较治疗前明显升高(P＜0.01),且治疗后治疗组AFI值明显高于对照组(P＜0.01),S/D值均较治疗前降低(P＜0.01),且治疗后治疗组S/D值低于对照组(P＜0.01),两组的生物物理评分比较差异无统计学意义(P＞0.05),治疗组的胎儿窘迫率、新生儿窒息率、羊水粪染率分别为11.1%、15.6%、20.0%,均显著低于对照组的32.6%、34.8%、39.1%,差异有统计学意义(P＜0.05),治疗组的早产率、剖宫产率分别为15.6%、22.2%,和对照组的17.4%、26.1%相比,差异无统计学意义(P＞0.05)。治疗组新生儿Apgar评分高于对照组,差异有统计学意义(P＜0.01)。结论：参芪增液活血汤结合补液治疗能改善妊娠晚期羊水偏少患者的宫内情况,降低胎儿窘迫、新生儿窒息、羊水粪染的发生率,提高新生儿质量,值得临床推广,超声能很好的反映羊水指数、脐带血流情况,值得普及。 |
| 英文摘要: |
| Objective: To evaluate the effect of Shenqi Zengye Huoxue Decoction (SQZYHXD) combined with rehydration therapy on the ultrasonographic index and pregnancy outcome of pregnant women with oligohydramnios in the third trimester of pregnancy. Methods: Using randomized parallel control method, 91 cases of oligohydramnios in the third trimester of pregnancy who met the inclusion criteria were divided into treatment group and control group, 46 cases in control group, 45 cases in treatment group and 45 cases in control group. The treatment group was treated with Shenqi Zengye Huoxue Decoction on the basis of the control group. Continuous treatment for 7 days was a course of treatment. The amniotic fluid index and umbilical artery collection of the two groups were observed by ultrasound comparison. Maximum systolic flow velocity/end diastolic flow velocity (S/D) and fetal biophysical score were used to compare the difference of pregnancy outcomes between the two groups. Results: After treatment, AFI in both groups was significantly higher than that before treatment (P < 0.01), and AFI in treatment group was significantly higher than that in control group (P < 0.01), and S/D in treatment group was lower than that before treatment (P < 0.01), and S/D in treatment group was lower than that in control group (P < 0.01). There was no significant difference in biophysical scores between the two groups (P > 0.05). Fetal distress rate and neonatal asphyxia in treatment group were not significantly different (P > 0.05). Interest rate and amniotic fluid fecal staining rate were 11.1%, 15.6% and 20.0% respectively, which were significantly lower than 32.6%, 34.8% and 39.1% of the control group (P < 0.05). The rates of premature delivery and cesarean section in the treatment group were 15.6% and 22.2%, respectively. There was no significant difference compared with 17.4% and 26.1% of the control group (P > 0.05). The Apgar score of neonates in the treatment group was higher than that in the control group (P < 0.01). Conclusions: Shenqi Zengye Huoxue Decoction combined with rehydration therapy can improve the intrauterine condition of patients with oligohydramnios in the third trimester of pregnancy, reduce the incidence of fetal distress, neonatal asphyxia, amniotic fluid fecal staining, improve the quality of newborns, which is worthy of clinical promotion. Ultrasound can well reflect the amniotic fluid index and umbilical cord blood flow, and it is worth popularizing. |
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