| 吴正海,王建.肝硬化患者大肠埃希菌血流感染预后的危险因素分析[J].浙江中西医结合杂志,2020,30(2): |
| 肝硬化患者大肠埃希菌血流感染预后的危险因素分析 |
| Analysis of risk factors for prognosis of Escherichia coli bloodstream infection in patients with liver cirrhosis |
| 投稿时间：2019-06-03 修订日期：2019-09-26 |
| DOI： |
| 中文关键词: 肝硬化 血流感染 医院感染 危险因素 |
| 英文关键词:Liver cirrhosis Bloodstream infection Nosocomial infection Risk factors |
| 基金项目: |
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| 中文摘要: |
| 目的 了解肝硬化患者大肠埃希菌血流感染30天内死亡的危险因素，为其治疗和预后提供参考。方法 采用回顾性病例对照研究，选择台州市第一人民医院近3年的112例肝硬化合并大肠埃希菌血流感染患者为研究对象，比较生存组和死亡组的临床特征，单因素和多因素Cox回归分析30天内死亡独立危险因素。结果 单因素分析显示入住ICU、医院感染、Child-Pugh分级、肝功能衰竭、感染性休克、并发症、白细胞总数、中性粒细胞百分比和12小时内合理使用抗生素是30天内死亡的危险因素（P?< 0.05）；多因素Cox回归分析显示医院感染、Child-Pugh分级、感染性休克、并发症及白细胞总数是30天内死亡的独立危险因素（P?< 0.05）。结论 肝硬化合并大肠埃希菌血流感染患者的30天死亡率与医院感染、Child-Pugh分级、感染性休克、并发症及白细胞总数密切相关。 |
| 英文摘要: |
| Objective To understand the risk factors of Escherichia coli bloodstream infection death within 30 days in patients with liver cirrhosis, and to provide references for its treatment and prognosis. Methods In this retrospective case control study, 112 cases of liver cirrhosis complicated with Escherichia coli bloodstream infection in the First People's Hospital of Taizhou in the past 3 years were selected as subjects. Clinical features of the survival group and death group were compared, and independent risk factors of death within 30 days were analyzed by univariate and multivariate Cox regression analysis. Results Univariate analysis showed that ICU admission, hospital infection, child-pugh classification, liver failure, septic shock, complications, white blood cell count, neutrophil percentage, and rational use of antibiotics within 12 hours were risk factors for death within 30 days (P < 0.05). Multivariate Cox regression analysis showed that hospital infection, child-pugh classification, septic shock, complications, and WBC count were independent risk factors for death within 30 days (P < 0.05). Conclusion The 30-day mortality of patients with liver cirrhosis complicated with Escherichia coli bloodstream infection was closely related to hospital infection, child-pugh classification, septic shock, complications, and WBC count. |
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