| 李滢,刘芳,冯利,陈双.甲状腺乳头状癌组织中miR-129表达情况及其与临床病理特征的相关性分析[J].浙江中西医结合杂志,2019,29(11): |
| 甲状腺乳头状癌组织中miR-129表达情况及其与临床病理特征的相关性分析 |
| Expression of miR-129 in Papillary Thyroid Carcinoma and Its Correlation with Clinicopathological Features |
| 投稿时间：2019-05-12 修订日期：2019-09-06 |
| DOI： |
| 中文关键词: 甲状腺乳头状癌 微小RNA-129 病理特征 相关性 |
| 英文关键词:PTC miR-129 Clinicopathological features Correlation |
| 基金项目: |
|
| 摘要点击次数: 733 |
| 全文下载次数: 2 |
| 中文摘要: |
| 目的 分析甲状腺乳头状癌(Papillary thyroid carcinoma,PTC)组织中微小RNA-129(miR-129)的表达情况,并探讨miR-129与PTC患者临床病理特征的相关性。方法 选取本院2010年11月至2014年2月收治的125例PTC患者作为研究对象,采用回顾性分析法分析所有患者的临床资料,收集125例PTC患者其125份癌组织(研究者)及125份癌旁正常甲状腺组织标本(对照组)作为研究对象,所有组织标本均行miR-129 mRNA检测,分析PTC组织中miR-129的表达与患者临床病理特征的关系。结果 ①PTC患者PTC癌变组织中miR-129 mRNA表达水平低于癌旁正常组织(P<0.05)；②miR-129的表达与PTC患者其年龄、性别、肿瘤大小情况均无明显关系(P>0.05),miR-129的表达与PTC患者临床分期、淋巴结转移及病理分级的表达有显著关系(P<0.05)；③经单因素分析得出：临床分期Ⅲ~Ⅳ期、有淋巴结转移及病理分级2级及miR-129水平低表达时患者生存时间均显著缩短(P<0.05)；④经多因素Cox分析得出：临床分期Ⅲ~Ⅳ期、有淋巴结转移及病理分级2级及miR-129水平低表达均为影响PTC患者预后的独立危险因素(HR=2.219,3.511,2.323,2.102)(P<0.05)。结论 miR-129在PTC患者组织中以低水平表达,临床分期Ⅲ~Ⅳ期、有淋巴结转移及病理分级2级时miR-129低表达率均上升,miR-129低表达PTC患者预后较差。 |
| 英文摘要: |
| Objective To investigate the expression of microRNA-129 (miR-129) in papillary thyroid carcinoma (PTC) and its correlation with clinicopathological features. Methods The clinical data of 125 cases of PTC patients in our hospital from November 2010 to February 2014 were analyzed retrospectively. The expression levels of miR-129 in the cancer tissues (n=125, study group) and adjacent normal tissues (n=125, control group) collected from the selected patients were detected. Then its correlation with clinicopathological features was analyzed. Results ①The expression level of microRNA-129 in PTC cancerous tissues of PTC patients was lower than that in normal tissues adjacent to cancer(P<0.05). ②The expression of miR-129 was not correlated with age, gender and tumor size of PTC patients (P>0.05), while was correlated with clinical stage, lymph node metastasis and pathological grade of PTC patients (P<0.05). ③Univariate analysis showed that the survival time of patients with stage III~IV, lymph node metastasis, pathological grade 2 and lower miR-129 level was significantly shorter (P<0.05). ④ Multivariate Cox analysis showed that clinical stage III~IV, lymph node metastasis and pathological grade 2 and low expression of miR-129 were independent risk factors for the prognosis of PTC patients(HR=2.219, 3.511, 2.323, 2.102)(P<0.05). Conclusion miR-129, is expressed at low levels in PTC patients. Patients with the clinical stage III~IV, lymph node metastasis and pathological grade 2, had lower expression level of miR-129. The prognosis of PTC patients with low expression of microRNA-129 was poor. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
