| 徐意.血清Mg7-Ag、PG、CEA联合ME-NBI诊断胃癌临床意义[J].浙江中西医结合杂志,2019,29(11): |
| 血清Mg7-Ag、PG、CEA联合ME-NBI诊断胃癌临床意义 |
| Clinical significance of serum Mg7-Ag, PG and CEA combined with ME-NBI in the diagnosis of gastric cancerXu Yi, Li Wei,Lou Miaozi, Xu Chao, Department of Gastroenterology, Jinhua Guangfu Hospital, Zhejiang 321000 |
| 投稿时间：2019-03-13 修订日期：2019-10-13 |
| DOI： |
| 中文关键词: 人胃癌MG7抗原 胃蛋白酶原 癌胚抗原 放大内镜结合窄带成像 胃癌 |
| 英文关键词:human gastric cancer MG7 antigen pepsinogen carcinoembryonic antigen magnifying endoscopy combined with narrowband imaging gastric cancer |
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| 中文摘要: |
| 目的：探讨血清人胃癌MG7抗原(Mg7-Ag)、胃蛋白酶原(PG)、癌胚抗原(CEA)联合放大内镜结合窄带成像(ME-NBI)诊断早期胃癌意义。方法：选择我院于2017年1月至2018年12月期间收治的胃癌患者97例作为观察组；另选择我院于2017年1月至2018年12月期间收治的胃粘膜病变患者83例作为对照组。所有研究对象均于入院后第2d清晨空腹抽取外周静脉血,分离血清,采用酶联免疫吸附法(ELISA法)测定血清Mg7-Ag和PG含量,采用微粒子免疫法测定CEA含量；采用ME-NBI技术诊断胃癌。结果：观察组血清Mg7-Ag和CEA水平高于对照组,而PG I低于对照组(P<0.05)。不同性别和年龄血清Mg7-Ag、PG I和CEA水平比较无统计学意义(P>0.05)；临床III~IV期血清Mg7-Ag和CEA水平高于I~II期,而PG I水平低于I~II期(P<0.05)。ME-BNI与病理诊断胃癌符合率为94.05%。Mg7-Ag、PG I、CEA联合ME-BNI诊断灵敏度和特异度高于各单项。结论：血清Mg7-Ag、PG、CEA联合ME-NBI诊断胃癌具有重要意义,具有良好诊断效能,值得临床借鉴。 |
| 英文摘要: |
| Objective: To investigate the significance of serum MG7 antigen (Mg7-Ag), pepsinogen (PG), carcinoembryonic antigen (CEA) combined with magnifying endoscopy and narrowband imaging (ME-NBI) in the diagnosis of early gastric cancer. Methods: 97 patients with gastric cancer admitted to our hospital from January 2017 to December 2018 were selected as observation group, and 83 patients with gastric mucosal lesions admitted to our hospital from January 2017 to December 2018 were selected as control group. Peripheral venous blood was taken from all subjects on the morning of the 2nd day after admission, and serum was separated. Serum Mg7-Ag and PG were measured by ELISA, CEA was measured by microparticle immunoassay, and gastric cancer was diagnosed by ME-NBI. Results: The serum levels of Mg7-Ag and CEA in the observation group were higher than those in the control group, and PG I n the observation group were lower than those in the control group(P<0.05). There was no significant difference in serum Mg7-Ag, PG I and CEA levels between different sexes and ages (P>0.05); serum Mg7-Ag and CEA levels in clinical stage III-IV were higher than those in stage I-II, while PG I levels were lower than those in stage I-II (P<0.05). The coincidence rate between ME-BNI and pathological diagnosis of gastric cancer was 94.05%. The diagnostic sensitivity and specificity of Mg7-Ag, PG I and CEA combined ME-BNI were higher than those of each single item. Conclusion: Serum Mg7-Ag, PG, CEA combined with ME-NBI in the diagnosis of gastric cancer is of great significance and has good diagnostic efficacy, which is worthy of clinical reference. |
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