| 秦福创,曾剑平.CatS与CysC在脑血管支架术后再狭窄形成过程中的作用研究[J].浙江中西医结合杂志,2019,29(10): |
| CatS与CysC在脑血管支架术后再狭窄形成过程中的作用研究 |
| Role of CatS and CysC in Restenosis after Cerebrovascular Stent Surgery |
| 投稿时间：2019-01-18 修订日期：2019-08-06 |
| DOI： |
| 中文关键词: CatS CysC 脑血管支架术 再狭窄 |
| 英文关键词:CatS CysC cerebral vascular stent restenosis |
| 基金项目:通过调控水通道蛋白 AQP1、AQP4 的表达研究其在 创伤性脑水肿发展过程中的动态变化及意义 |
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| 中文摘要: |
| 目的 探讨脑血管支架术后再狭窄形成过程中,血清组织蛋白酶S(CatS)和胱抑素C（CysC）的作用。方法 选取2007年3月至2017年1月在我院治疗的脑血管狭窄患者90例，随访观察患者术后再狭窄发生情况以及患者CatS和CysC变化情况。结果 随访发现术后出现脑动脉再狭窄患者22例，未出现脑动脉再狭窄患者68例；术前脑动脉狭窄程度越高的患者，其CatS和CysC水平越高，其中脑动脉狭窄程度＞90%的患者，CatS和CysC水平最高；再狭窄组患者术后3个月、6个月CatS和CysC水平均明显高于无再狭窄组患者，差异有统计学意义（p＜0.05）；再狭窄组△CatS和△CysC分别为（0.41±0.08）nmol/L和（0.19±0.09）mg/L，明显高于无再狭窄组，差异有统计学意义（p＜0.05）。结论 血清CatS与CysC在脑血管支架术后再狭窄形成过程中起重要作用，监测血清CatS与CysC在评估再狭窄中有一定价值。 |
| 英文摘要: |
| Objective: Study on cerebral vascular restenosis after stent placement in the formation process of serum cathepsin S (CatS) and cystatin C (CysC) function.Methods: From 2007 March to 2014 January, 90 patients with cerebral vascular stenosis in our hospital treatment, follow-up observed patients with postoperative restenosis and CatS ,CysC changes.Results: Follow-up postoperative cerebral artery restenosis in 22 patients, no cerebral artery restenosis 68 patients; The higher the degree of preoperative arterial stenosis in patients, the CatS and CysC level is higher, cerebral artery stenosis the degree＞90% patients, CatS and CysC levels in the highest; Restenosis group patients postoperative 3 months and 6 months CatS and CysC levels were significantly higher than that of non restenosis group of patients, the difference was statistically significant (P < 0.05);Restenosis group △CatS and △CysC were (0.41±0.08) nmol/L and (0.19±0.09) mg/L, significantly higher than the non restenosis group, the difference was statistically significant (P < 0.05).Conclusion: Serum CatS and CysC in cerebral vascular stent restenosis formation process plays an important role , monitoring of serum CatS and CysC in the evaluation of restenosis has certain value. |
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