| 李温如,马丽俐,陈志伟.疏肝补肾法对女性肝郁肾虚型黄褐斑患者抗氧化作用的影响[J].浙江中西医结合杂志,2019,29(8): |
| 疏肝补肾法对女性肝郁肾虚型黄褐斑患者抗氧化作用的影响 |
| Clinical Efficacy of Smoothing Liver and Nourishing Kidney Therapy on Female Melasma of Liver Stagnation and Kidney Deficiency Type and the Influence on Antioxidation. |
| 投稿时间：2019-01-07 修订日期：2019-05-05 |
| DOI： |
| 中文关键词: 疏肝补肾法 黄褐斑 肝郁肾虚 抗氧化 超氧化物歧化酶 丙二醛 总巯基 |
| 英文关键词:Smoothing Liver and Nourishing Kidney therapy Melasma Liver Stagnation and Kidney Deficiency Antioxidant SOD MDA Total (-SH) |
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| 中文摘要: |
| 目的：观察疏肝补肾法治疗女性肝郁肾虚型黄褐斑患者抗氧化作用的影响。方法：1.采用随机对照方法，将70例中医分型为肝郁肾虚型的女性黄褐斑患者随机分为中药组、成药组，每组各35例。中药组口服疏肝补肾汤，成药组口服六味地黄丸和红花逍遥胶囊，两组均外用广谱防晒霜。4周为1个疗程，连续治疗12周；2.选取30例健康女性志愿者为正常对照组，于治疗前后检测两组患者血清超氧化物歧化酶（SOD）、丙二醛（MDA）、总巯基（-SH）水平，并与正常对照组比较，观察疏肝补肾法对抗氧化作用的影响。结果：1.与正常对照组相比，治疗前两组患者血清SOD、总（-SH）含量均明显下降，MDA含量明显升高，差异有统计学意义（P＜0.01）。2.治疗前后比较，治疗后两组患者血清SOD、总（-SH）明显升高，MDA明显降低，差异有统计学意义（P＜0.01）。3.治疗后两组组间比较，对氧化/抗氧化功能的调节作用，中药组优于成药组，差异有统计学意义（P＜0.05）。结论：疏肝补肾法通过改善氧化/抗氧化作用，调节黑素代谢，能够有效治疗女性肝郁肾虚型黄褐斑。 |
| 英文摘要: |
| Objective: TO observe the clinical efficacy of smoothing liver and nourishing kidney therapy on female melasma of liver stagnation and kidney deficiency type and the influence on antioxidation. Methods:1. 70 patients were randomly divided into two groups：traditional Chinese medicine group, Chinese patent drug group, 35 patients in each group. Traditional Chinese medicine group were given Shugan Bushen Decoction, Chinese patent drug group were given Liu-Wei Tonic Tablets and Safflower Xiaoyao Capsules orally. Two groups all used topical broad-spectrum sunscreen. 4 weeks for a course of treatment and each group took 12 weeks of consecutive treatment. 2.30 healthy volunteers in normal control group, serum Superoxide dismutase(SOD), malondialdehyde(MDA) and total sulfhydryl(-SH) contents of two groups were detected and compared with normal control group before and after treatment, the influence on antioxidation was observed. Results: 1.Compared with normal control group, serum SOD, total (-SH) contents of two groups were significantly decreased while MDA content was significantly increased before treatment,. 2.After treatment, serum SOD, total (-SH) contents of two groups increased and MDA content decreased significantly, the difference was statistically significant (P＜0.01)。3.Compared among the two groups, the difference was statistically significant (P＜0.05). Conclusion: Smoothing liver and nourishing kidney therapy can effectively treat female melasma of liver stagnation and kidney deficiency type by adjusting the antioxidantion effect and regulating melanin metabolism. |
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