| 傅雪丽.脑安滴丸联合奥拉西坦对血管性痴呆患者临床疗效观察及对细胞因子影响研究[J].浙江中西医结合杂志,2020,30(3): |
| 脑安滴丸联合奥拉西坦对血管性痴呆患者临床疗效观察及对细胞因子影响研究 |
| Clinical Observation of Naoan Dropping Pills Combined with Oxiracetam on Patients with Vascular Dementia and Its Effect on CytokinesFu Xueli Huang Lifen Lishui Second People |
| 投稿时间：2019-01-07 修订日期：2019-10-21 |
| DOI： |
| 中文关键词: 脑安滴丸 奥拉西坦 血管性痴呆 疗效 细胞因子 |
| 英文关键词:Naoan dropping pills Oxiracetam Vascular dementia Therapeutic effect Cytokines |
| 基金项目: |
|
| 摘要点击次数: 499 |
| 全文下载次数: 1 |
| 中文摘要: |
| 目的：探讨脑安滴丸联合奥拉西坦对血管性痴呆患者临床疗效及对细胞因子影响。方法：收治的103例血管性痴呆患者,按照随机表法分为对照组51例与观察组52例。对照组患者给予奥拉西坦治疗,观察组在对照组基础上结合脑安滴丸治疗。两组疗程均为4周。比较两组治疗疗效,治疗前后长谷川痴呆量表(HDS)、简易精神状态量表(MMSE)和日常生活能力量表(ADL)及细胞因子变化,及不良反应。结果：观察组总有效率为92.31%,高于对照组72.55%(P<0.05)。两组治疗后HDS和MMSE评分增加,而ADL评分降低(观察组：t=10.929、14.555、13.531,对照组：t=7.039、11.691、11.901,P<0.05)；观察组治疗后HDS和MMSE评分高于对照组,而ADL评分低于对照组(t=4.479、7.388、7.086,P<0.05)。两组治疗后血清IL-6、IL-18和TNF-α水平降低(观察组：t=46.222、30.701、24.149,对照组：t=30.071、19.036、8.396,P<0.05)；观察组治疗后血清IL-6、IL-18和TNF-α水平低于对照组(t=14.349、11.797、12.071,P<0.05)。观察组不良反应(3.85%)低于对照组(17.65%)(P<0.05) 。结论：脑安滴丸联合奥拉西坦对血管性痴呆患者临床疗效良好,且可减轻患者炎症反应,改善患者认知功能和痴呆症状,及提高患者日常生活能力,值得临床借鉴。 |
| 英文摘要: |
| Objective: To investigate the clinical effect of Naoan Dropping Pills combined with Oxiracetam on vascular dementia and its effect on cytokines. Methods: The 103 patients with vascular dementia admitted to our hospital from January 2017 to June 2018 were randomly divided into control group (51 cases) and observation group (52 cases). The patients in the control group were treated with oxiracetam, while the patients in the observation group were treated with Naoan dripping pills on the basis of the control group. Both groups were treated for 4 weeks. The therapeutic effects, changes of HDS, MMSE, ADL, cytokines and adverse reactions before and after treatment were compared between the two groups. Results: The observation group total effective rate was 92.31%, which was higher than 72.55% of the control group (P<0.05). After treatment, HDS and MMSE scores increased, while ADL scores decreased in both groups (observation group: t=10.929, 14.555, 13.531, control group: t=7.039, 11.691, 11.901, P<0.05); after treatment, HDS and MMSE scores in observation group were higher than those in control group, while ADL scores were lower than those in control group (t=4.479, 7.388, 7.086, P<0.05). After treatment, the levels of serum IL-6, IL-18 and TNF-a in the two groups decreased (observation group: t=46.222, 30.701, 24.149, control group: t=30.071, 19.036, 8.396, P<0.05); after treatment, the levels of serum IL-6, IL-18 and TNF-a in the observation group were lower than those in the control group (t=14.349, 11.797, 12.071, P<0.05). The adverse reactions in the observation group (3.85%) were lower than those in the control group (17.65%) (P<0.05). Conclusion: Naoan dropping pill combined with oxiracetam has a good clinical effect on vascular dementia patients, and can alleviate inflammation, improve cognitive function and dementia symptoms, and improve daily living ability of patients, which is worthy of clinical reference. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
