| 陈英,葛叶波.丁苯酞软胶囊联合倍他司丁治疗血管源性眩晕疗效及对氧化应激和炎性因子的影响[J].浙江中西医结合杂志,2019,29(10): |
| 丁苯酞软胶囊联合倍他司丁治疗血管源性眩晕疗效及对氧化应激和炎性因子的影响 |
| Curative efficacy of butylphthalide soft capsules in combination with betahistine in patients with vascular vertigo and its influences on oxidative stress and inflammatory factors |
| 投稿时间：2019-01-06 修订日期：2019-07-30 |
| DOI： |
| 中文关键词: 丁苯酞软胶囊 倍他司丁 血管源性眩晕 氧化应激 炎性因子 |
| 英文关键词:Butylphthalide soft capsules betahistine vascular vertigo oxidative stress inflammatory factors |
| 基金项目: |
|
| 摘要点击次数: 709 |
| 全文下载次数: 2 |
| 中文摘要: |
| 目的：探讨丁苯酞软胶囊联合倍他司丁治疗血管源性眩晕疗效及对患者氧化应激和炎性因子的影响。
方法：收集116例血管源性眩晕患者作为观察对象，随机分为对照组和观察组，每组各58例。常规治疗基础上，对照组给予倍他司丁治疗，观察组给予丁苯酞软胶囊联合倍他司丁治疗。治疗2周后，比较两组患者临床疗效、临床症状积分、氧化应激指标及炎性因子水平。
结果：2周后，疗效评价显示，观察组血管源性眩晕患者治疗总有效率高于对照组（94.8% vs 81.0%），组间比较有统计学差异（P＜0.05）。治疗后，与对照组相比，观察组临床症状积分降低（P＜0.05）。氧化应激指标显示，与对照组相比，观察组患者丙二醛（MDA）水平降低，超氧化物歧化酶（SOD）水平升高（P均＜0.05）。炎性因子水平显示，观察组患者治疗后肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）等炎性因子水平降低，组间比较都有统计学差异（P均＜0.05）。
结论：丁苯酞软胶囊联合倍他司丁是血管源性眩晕的有效治疗方案，能够有效改善患者临床症状，并减轻氧化应激和炎性反应。 |
| 英文摘要: |
| Abstract
Objective: To investigate the curative efficacy of butylphthalide soft capsules in combination with betahistine in patients with vascular vertigo and its influences on oxidative stress and inflammatory factors.
Methods: 116 patients with vascular vertigo were collected as observational objects to be randomly divided into the control group and the observation group with 58 cases in each group. Besides conventional treatment, the control group was given treatment of betahistine, while the observation group was given treatment of butylphthalide soft capsules in combination with betahistine. After 2 weeks, the curative efficacy, scores of symptoms, indices of oxidative stress and levels of inflammatory factors were compared between the two groups.
Results: After 2 weeks, assessment of curative efficacy showed that the observation group had higher total therapeutic efficacy ratio than that in the control group with statistical difference (94.8% vs 81.0%, P<0.05). After treatment, in comparison with the control group, the observation group had statistically lower score of symptoms (P<0.05). Indices of oxidative stress showed that the observation group had lower level of malondialdehyde (MDA) and higher level of superoxide dismutase (SOD) with both statistical differences (both P<0.05). In comparison with the control group after treatment, the observation group had lower levels of inflammatory factors of tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) with both statistical differences (both P<0.05).
Conclusion: Butylphthalide soft capsules in combination with betahistine is an effective therapeutic scheme for patients with vascular vertigo, which can effectively improve clinical symptoms. And it can alleviate oxidative stress and inflammatory reaction. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
