| 林敏秀,张琴,曹珊珊,张隆英,陈崇阳.EPB41L3和骨膜蛋白在宫颈癌组织中的表达及意义[J].浙江中西医结合杂志,2019,29(10): |
| EPB41L3和骨膜蛋白在宫颈癌组织中的表达及意义 |
| Expressions and significance of EPB41L3 and periostin in the cervical cancer tissue. |
| 投稿时间：2018-12-22 修订日期：2019-06-06 |
| DOI： |
| 中文关键词: 宫颈癌 EPB41L3 骨膜蛋白 发病机制 转移 |
| 英文关键词:cervical cancer EPB41L3 periostin pathogenesis metastasis |
| 基金项目:温岭市科技局基金资助项目( 2018C312033) |
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| 中文摘要: |
| 【】 目的 观测EPB41L3和骨膜蛋白在宫颈癌组织中的表达,探讨它们在宫颈癌发病机制中的作用。方法 选取70例宫颈癌及50例慢性宫颈炎组织标本,免疫组化法检测EPB41L3和骨膜蛋白的表达水平。结果 宫颈癌组EPB41L3的阳性率和表达强度均显著低于慢性宫颈炎组(74.29% VS 92.00%；0.18±0.03 VS 0.24±0.04 OD值)(均P<0.01),宫颈癌组骨膜蛋白的阳性率和表达强度均显著高于慢性宫颈炎组(84.29% VS 54.00%；0.27±0.05 VS 0.17±0.04 OD值)(均P<0.01)。伴有淋巴结转移的宫颈癌组骨膜蛋白的阳性率和表达强度均显著高于不伴有淋巴结转移组(96.77% VS 74.36%；0.29±0.04 VS 0.26±0.06 OD值)(P<0.05或P<0.01),EPB41L3的阳性率和表达强度在伴有与不伴有淋巴结转移组间差异无统计学意义(67.74% VS 79.49%；0.19±0.04 VS 0.18±0.03 OD值)(均P >0.05)。结论 在宫颈癌组织中EPB41L3的表达下降,骨膜蛋白的表达却增强,它们可能与宫颈癌的恶性分化相关,有望成为一种治疗肿瘤的新靶点。 |
| 英文摘要: |
| 【】 Objective To investigate the potential roles of erythrocyte membrane protein band 4.1-like 3 (EPB41L3) and periostin in the pathogenesis of the cervical cancer,the expressions of EPB41L3 and periostin at the cervical cancer tissue were observed. Methods Tissues from 70 cases of patients with cervical cancer, and 50 cases of chronic cervicitis were obtained. Immunohistochemistry was performed to determine the expressions of EPB41L3 and periostin protein in this tissues. Results The positive rate and expressions of EPB41L3 in cervical cancer group were significantly lower than in chronic cervicitis group (74.29% VS 92.00%；0.18±0.03 VS 0.24±0.04 optical density, respectively)(all P<0.01),but the positive rate and expressions of periostin in cervical cancer group were significantly higher than those in chronic cervicitis group (84.29% VS 54.00%；0.27±0.05 VS 0.17±0.04 optical density, respectively)(all P<0.01). Moreover, in cervical cancer group, those with lymph node metastasis were demonstrated higher positive rate and levels of periostin than those without lymph node metastasis((96.77% VS 74.36%；0.29±0.04 VS 0.26±0.06 optical density, respectively)(P<0.05 or P<0.01), while there were no significance of positive rate and levels of EPB41L3 between in those with or without lymph node metastasis (67.74% VS 79.49%；0.19±0.04 VS 0.18±0.03 optical density, respectively)(all P>0.05). Conclusion Expression levels of EPB41L3 was decreased in cervical cancer, on the other hand,the expression levels of periostin were increased. They may be correlated with cervical cancer cell malignant differentiation. They may be play a key roles as a novel target for tumor therapy. |
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