| 朱文刚.加速康复外科对腹腔镜结直肠癌手术患者临床效果观察及对术后炎性细胞因子影响研究[J].浙江中西医结合杂志,2019,29(11): |
| 加速康复外科对腹腔镜结直肠癌手术患者临床效果观察及对术后炎性细胞因子影响研究 |
| Clinical effect of accelerated rehabilitation surgery on patients undergoing laparoscopic colorectal cancer surgery and its effect on inflammatory cytokinesZhu Wengang, Chief Physician of General Surgery, Fourth People |
| 投稿时间：2018-11-26 修订日期：2019-07-01 |
| DOI： |
| 中文关键词: 加速康复外科 腹腔镜结直肠癌手术 临床效果 炎性细胞因子#$NL |
| 英文关键词:accelerated rehabilitation surgery laparoscopic colorectal cancer surgery clinical effect inflammatory cytokines |
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| 中文摘要: |
| 目的：探讨加速康复外科对腹腔镜结直肠癌手术患者临床效果及对患者术后炎性细胞因子影响。方法：选择2016年8月至2018年8月期间我院收治的腹腔镜结直肠癌手术患者107例,依据随机数字表法随机分为对照组53例与观察组54例。对照组采用传统康复,观察组采用加速康复外科干预。比较两组手术指标、术后机体功能恢复情况,术前、术后1d和术后3d血清炎性细胞因子变化,及患者生活质量改善情况。结果：观察组术中出血量和手术时间与对照组比较, 无显著性意义(P>0.05)；观察组住院时间短于对照组(P<0.05)。观察组首次下床活动时间、排便时间以及排气时间快于对照组(P<0.05)。两组术后1d和术后3d血清TNF-α和IL-6水平较术前升高,而术后3d较术后1d降低(P<0.05)；观察组术后1d和术后3d血清TNF-α和IL-6水平低于对照组(P<0.05)。观察组WHOQOL-BREF评分高于对照组(P<0.05)。结论：加速康复外科对腹腔镜结直肠癌手术患者临床效果显著,可维持患者术后炎症状态,改善患者生活质量,值得进一步推广应用。 |
| 英文摘要: |
| Objective: To investigate the clinical effect of accelerated rehabilitation surgery on patients undergoing laparoscopic colorectal cancer surgery and its influence on inflammatory cytokines after operation. Methods: 107 patients with colorectal cancer underwent laparoscopic surgery in our hospital from August 2016 to August 2018 were randomly divided into control group (53 cases) and observation group (54 cases) according to random number table method. The control group was treated with traditional rehabilitation, while the observation group was treated with accelerated rehabilitation surgery. The changes of serum inflammatory cytokines and the improvement of patients"quality of life were compared between the two groups before operation, 1 day after operation and 3 days after operation. Results: There was no significant difference in bleeding volume and operation time between the observation group and the control group (P>0.05), and the hospitalization time of the observation group was shorter than that of the control group (P<0.05). The time of first ambulation, defecation time and exhaust time of the observation group were faster than those of the control group (P<0.05). The levels of TNF-a and IL-6 in serum of the two groups increased at 1 day and 3 days after operation, but decreased at 3 days after operation compared with 1 day after operation (P<0.05); the levels of TNF-a and IL-6 in serum of the observation group were lower than those of the control group at 1 day and 3 days after operation (P<0.05). The WHOQOL-BREF score of the observation group was higher than that of the control group (P<0.05). Conclusion: Accelerated rehabilitation surgery has a significant clinical effect on patients undergoing laparoscopic colorectal cancer surgery. It can maintain the inflammatory state of patients after operation and improve the quality of life of patients. It is worthy of further promotion and application. |
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