| 李艳,徐颖颖,张琳,王平.外用咪喹莫特诱发皮肤白斑2例及分析[J].浙江中西医结合杂志,2019,29(7): |
| 外用咪喹莫特诱发皮肤白斑2例及分析 |
| Imiquimod-induced localized vitiligo-like depigmentation,2 cases report |
| 投稿时间：2018-11-14 修订日期：2019-01-30 |
| DOI： |
| 中文关键词: 咪喹莫特 色素脱失 |
| 英文关键词:imiquimod depigmentation |
| 基金项目: |
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| 中文摘要: |
| 咪喹莫特是一种免疫反应调节剂,用于外生殖器与肛周疣、浅表性基底细胞癌及日光性角化病的外用治疗。咪喹莫特外用最常见的副作用是伴有瘙痒或烧灼感的局部刺激反应,白癜风样色素脱失临床极其少见。本文报道外用5%咪喹莫特乳膏分别用于治疗生殖器尖锐湿疣2月后和面部扁平疣4周后,用药部位出现永久性皮肤白斑,其机制可能与局部天然免疫和细胞免疫应答有关。临床医师或药师均需要警惕咪喹莫特可能导致皮肤永久性白斑,尽量不用于面部,以免造成毁容性不良反应。 |
| 英文摘要: |
| Imiquimod,an imidazoquinoline amine, is a potent topical immune response modifier that can be topically delivered as a cream for treating external genital warts, superficial basal cell carcinoma and actinic keratoses. In our article, we report two cases of cutaneous depigmentation induced by imiquimod and summarize the existing literature regarding this side effect. Clinicians and pharmacists should be made aware of the possible pigmentary changes associated with application of this cream. |
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