| 陈金莹.左乙拉西坦联合拉莫三嗪治疗癫痫部分性发作的临床疗效及对脑电图变化和认知功能的影响[J].浙江中西医结合杂志,2019,29(8): |
| 左乙拉西坦联合拉莫三嗪治疗癫痫部分性发作的临床疗效及对脑电图变化和认知功能的影响 |
| Clinical Efficacy of Levetiracetam Combined with Lamotrigine on EEG Changes and Cognitive Function in the Treatment of Partial-Onset Seizures |
| 投稿时间：2018-10-18 修订日期：2019-02-16 |
| DOI： |
| 中文关键词: 左乙拉西坦 拉莫三嗪 癫痫 临床疗效 脑电图 认知功能 |
| 英文关键词:Levetiracetam Lamotrigine Epilepsy Clinical efficacy EEG Cognitive function |
| 基金项目:拉莫三嗪在老年癫痫患者应用有效性及安全性的研究.项目编号：2013059-23 |
|
| 摘要点击次数: 775 |
| 全文下载次数: 3 |
| 中文摘要: |
| 目的: 观察左乙拉西坦联合拉莫三嗪治疗癫痫部分性发作的临床疗效及对脑电图变化和认知功能的影响。方法: 选择2016年2月-2018年1月我院新诊断的癫痫部分性发作98例患者纳入研究，按照随机数字表法分为对照组与研究组，各48例。对照采用单纯药物拉莫三嗪治疗，研究组采用左乙拉西坦与拉莫三嗪联合治疗。比较两组临床疗效、脑电频率（α、θ、δ）、脑电图评定、认知功能评分变化。结果：研究组的总有效率（93.75%）明显高于对照组（79.16%），两组比较有明显差异（χ2=4.360，P=0.037）；治疗前，两组患者α、θ、δ比较无明显差异（P>0.05），治疗后，研究组患者α明显低于对照组（t=11.325，P<0.05），θ、δ明显高于对照组（t=12.634，t=1.988，P<0.05）；研究组脑电图评定的总有效率（85.41 %）明显高于对照组（66.67 %）（χ2=4.631，P=0.031）；治疗前，认知功能评分组间比较无差异（P>0.05），治疗后，研究组患者认知功能评分明显高于对照组（t=6.779，P<0.001）。结论：左乙拉西坦和拉莫三嗪联用治疗癫痫部分性发作患者疗效显著，能够安全有效的控制癫痫发作，改善患者的认知功能，值得临床推广应用。 |
| 英文摘要: |
| Objective To investigate the clinical efficacy of levetiracetam combined with lamotrigine on EEG changes and cognitive function in the treatment of partial-onset seizures. Methods 98 cases of partial-onset seizures newly-diagnosed in our hospital from February 2016 to January 2018 were selected and divided into two groups according to the random table method, reach with 48 cases. The control group received the lamotrigine, while the study group received the levetiracetam combined with lamotrigine. Then the clinical efficacy, EEG frequency (α, θ, δ), EEG assessment, and cognitive function scores were compared between the two groups. Results The total effective rate of the study group was significantly higher than that of the control group (93.75% vs79.16%, χ2=4.360, P=0.037). The frequency of α, θ and δ between the two groups had no difference before treatment (P>0.05). After treatment, the study group had lower frequency of α (t=11.325, P<0.05) as well as higher frequency of θ and δ than those of the control group (t=12.634, t=1.988, P<0.05). The total effective rate of EEG assessment in the study group was significantly higher than that of the control group (85.41 % vs 66.67 %, χ2=4.631, P=0.031). The cognitive function scores had no difference before treatment, and were higher in the study group than in the control group after treatment (t=6.779, P<0.001). Conclusion The application of levetiracetam combined with lamotrigine can effectively control the onset of seizures and ameliorate the cognitive function of patients with partial-onset seizures, which is worthy of promotion. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
