| 周晓慧,张楠,徐云芬.芪明颗粒联合利拉鲁肽对糖尿病肾病HIF-1α和VEGF水平的影响[J].浙江中西医结合杂志,2019,29(8): |
| 芪明颗粒联合利拉鲁肽对糖尿病肾病HIF-1α和VEGF水平的影响 |
| Effect of Qiming Granules Combined with Liraglutide on the Levels of HIF-1α and VEGF in Diabetic Nephropathy |
| 投稿时间：2018-10-09 修订日期：2019-07-06 |
| DOI： |
| 中文关键词: 糖尿病肾病 芪明颗粒 利拉鲁肽 诱导因子-1α 血管内皮生长因子 |
| 英文关键词:Diabetic Nephropathy Qiming Granules Liraglutide Inducible Factor-1α Vascular Endothelial Growth Factor |
| 基金项目:课题：浙江省自然科学基金 项目编号 Y16H070002 |
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| 中文摘要: |
| 目的 探讨芪明颗粒联合利拉鲁肽对糖尿病肾病(DN)患者HIF-1α以及VEGF水平的影响。方法 选取2016年12月-2018年2月本院DN患者122例,按照随机数字表法分为两组(联合组、对照组),每组各61例。对照组行控糖基础治疗+利拉鲁肽治疗,联合组在对照组的基础上加用芪明颗粒治疗,对比两组治疗前、治疗6个月后肾功能指标、血糖指标、血脂指标、低密度脂蛋白胆固醇及血清 HIF-1α、VEGF 水平变化。结果 两组治疗后的BUN、Cys-C、Scr、24hUAER指标均比治疗前降低,联合组指标改善情况相比对照组优,差异具有统计学意义(P＜0.05)；两组治疗后的FBG、HbAlc水平比治疗前均有下降,联合组指标改善情相比对照组优,差异具有统计学意义(P＜0.05)；用药后,两组患者血糖指标TG、TC、LDL-C水平比治疗前均有下降,HDL-C水平有所上升,联合组指标改善相比对照组好,差异有统计学意义(P＜0.05)；用药后,两组患者HIF-1α、VEGF水平比用药前均有下降,联合组改善相比对照组优,差异具有统计学意义(P＜0.05)。结论 中西医联合用药治疗NA,能够有效降低患者血糖、血脂水平,改善肾功能,降低HIF-1α、VEGF水平。 |
| 英文摘要: |
| Objective To explore the effects of Qiming Granules combined with Liraglutide on the levels of HIF-1α and VEGF in patients with diabetic nephropathy (DN). Methods A total of 122 patients with DN in the Hospital between December 2015 and February 2018 were enrolled. The patients were divided into two groups (a combined treatment group and a control group) according to the random number table, with 61 cases in each group. The control group was treated with glucose control combined with Liraglutide, and the combined treatment group was treated with Qiming Granules on the basis of treatment given to the control group. The renal function index, blood glucose index and blood lipid index, low-density lipoprotein cholesterol and serum levels of HIF-1α and VEGF before treatment and after 6 months were compared between the two groups. Results The BUN, Cys-C, Scr and 24hUAER indexes in both groups were shown to be lower than before treatment, with improvement in the combined treatment group more significant than that in the control group (P<0.05). The levels of FBG and HbAlc were lower than that before treatment in both groups, with improvement in the combined treatment group more significant than that in the control group (P<0.05). The blood glucose levels of TG, TC and LDL-C in both groups were reduced and HDL-C increased than before treatment, with improvement in the combined treatment group more significant than that in the control group. The difference was statistically significant (P<0.05). The levels of HIF-1α and VEGF in both groups were decreased after medicine administration, with improvement in the combined treatment group more significant than the control group, and the difference was statistically significant (P<0.05). Conclusion For the treatment of NA, traditional Chinese medicine combined with western medicine can help reduce the levels of blood glucose and blood lipid, improve the patients’ renal function and reduce the levels of HIF-1α and VEGF. |
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