| 徐潘,李锐,谢作钢,何卫,陈盛镱,欧洋帆,郭高凡.精浆β-内啡肽和前列腺素E<sub>2</sub>与慢性盆腔疼痛综合征疼痛症状关系的研究[J].浙江中西医结合杂志,2019,29(3): |
| 精浆β-内啡肽和前列腺素E<sub>2</sub>与慢性盆腔疼痛综合征疼痛症状关系的研究 |
| The pain symptoms of chronic pelvic pain syndrome relates to seminal plasma beta-endorphin and prostaglandin E<sub>2 </sub> |
| 投稿时间：2018-08-02 修订日期：2019-01-09 |
| DOI： |
| 中文关键词: 慢性盆腔疼痛综合征 β-内啡肽 前列腺素E2 |
| 英文关键词:Chronic pelvic pain syndrome beta-endorphin prostaglandin E2 |
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| 中文摘要: |
| 目的 探讨精浆中β-EP和PGE<sub>2</sub>与CPPS疼痛症状的相关性。方法 本研究选择符合诊断标准的A组(NIH-CPSI疼痛评分≥14分)、B组(NIH- CPSI疼痛评分＜14分)各30例CPPS患者,同时设正常组24例。采用ELISA法检测精浆中β-EP和PGE<sub>2</sub>浓度,并对疼痛症状与精浆中β-EP和PGE<sub>2</sub>相关性进行分析。结果 A组,B组β-EP浓度均低于正常组( P均＜0.05)；且A组低于B组( P＜0.05)。 A组,B组PGE<sub>2</sub>浓度均高于正常组( P均＜0.05)；且 A组高于B组( P＜0.05)。结论 CPPS疼痛症状与患者精浆中β-EP和PGE<sub>2</sub>浓度有关,疼痛症状越明显,β-EP浓度越低,PGE<sub>2</sub>浓度越高。 |
| 英文摘要: |
| Abstract Objective To investigate the relationship of the pain symptoms of chronic pelvic pain syndrome(CPPS) with the contents of beta-endorphin (β-EP)and prostaglandin E2 (PGE2)in the seminal plasma.Methods We observed 60 cases of CPPS,which were divided into two groups (group A,n = 30,NIH-CPSI score≥14;group B,n = 30,NIH-CPSI score＜14),NIH-Chronic prostatitis symptom index (NIH-CPSI)score was done in all patients.Another 24 normal healthy men were enrolled as controls.We measured the contents of β-EP and PGE2 in the seminal plasma by ELISA,and analyzed their relationship with the pain symptoms of CPPS.Results The levels of β-EP in group A,B were lower than normal group(all P＜0.05),group A lower than group B( P＜0.05).The levels of PGE2 in group A,B were higher than normal group(all P＜0.05),group A higher than group B( P＜0.05).Conclusion In the seminal plasma of CPPS patients，the content of β-EP ismarkedly reduced and that of PGE2 significantly elevated，which suggests that they may be involved in the inflammatory reaction of CPPS． |
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