| Objective To explore the clinical improvement of N-acetylcysteine (NAC) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and evaluate serum procalcitonin (PCT), prealbumin (PA) and antioxidant damage impact, analysis of its mechanisms. Methods 98 patients with AECOPD in hospital from February in 2015 to March in 2017 were selected and randomly divided into control group and treatment group. 49 patients in each group. Control group were treated with routine treatment,and the treatment group was treated with NAC on the basis of the control group treatment. Evaluated the blood gas analysis results of the two groups and improvement of the breathing and symptoms, and detected the levels of serum PCT, PA and malondialdehyde (MDA).Results PaO2 and PA of the treatment group were (74.20±7.39) mmHg and (274.83±15.74) mg/L respectively, higher than those of the control group (71.27±7.16) mmHg and (261.36±14.87) mg/L,the difference was statistically significant (P<0.05).PaCO2, PCT, MDA and respiratory distress index (mMRC) and COPD symptom score (CAT score) of the treatment group were (36.15±4.26) mmHg and (6.05±0.39) μg/L respectively,lower than the control group (35.28±5.30) μmol/L, (1.63±0.42) points,(10.02±1.12) points, (39.78±4.72) mmHg, (7.61±0.41) μg/L amd (42.38±5.96) μmol/L,(1.85±0.49) points and (11.46±1.20) points,the difference was statistically significant(P<0.05). Conclusion For patients with AECOPD, the use of NAC adjuvant therapy can significantly improve the patient"s symptoms and blood culture status, down-regulate the levels of PCT and MDA, and increase serum prealbumin levels. Its mechanism of action is related to antioxidative damage. |
